Current Organic Chemistry - Volume 7, Issue 5, 2003

This article (the first of three parts) reviews the use of 1,3-dipolar cycloaddition reactions of nitrile oxides and nitronates in the construction of carbohydrate mimics. Preparation of isoxazolidine and other modified nucleosides, isoxazolidine fused systems, C-disaccharides, polyhydroxylated and aminopolyhydroxylated carbocycles and azasugars, amino sugars, polyhydroxylated alkaloids of the pyrrolidine and indolizidine seri Read More

The specific recognition of any given DNA sequence by ligands is expected to revolutionize medicine and biotechnology in the future. Using oligonucleotides as sequence-specific ligands to form triple helical structures offers a particularly attractive approach due to their availability and their simple recognition code based mainly on directional hydrogen bond contacts. However, the recognition code is limited to only two Read More

Higher 3-deoxy-2-ulosonic acids are a family of widely distributed natural high carbon carbohydrates, of which 3-deoxy-Δ-arabino-hept-2-ulosonic acid (DAH), 3-deoxy-Δ-manno-oct-2-ulosonic acid (KDO, 2), 3-Deoxy-Δ-glycero-Δ-galacto-non-2-ulosonic acid (KDN) and 5-acetamido-3,5-dideoxy-Dglecero- Δ-galacto-non-2-ulosonic acid (N-acetylneuraminic acid) are the most common members. These sugars have been demonstr Read More

Phosphines play an important role in organometallic chemistry, homogeneous catalysis and synthetic chemistry. Traditionally, phosphines are mainly prepared by one of the following methods: reaction of halophosphines with organometallic reagents, reaction of phosphides with halides, addition of RR'PH to C-C multiple bonds, Friedel-Crafts reactions and reduction of phosphine oxides. In the past one decade or so, power Read More