Current Organic Chemistry - Volume 7, Issue 10, 2003

In the Past, the term heterocyclic compounds would invoke in the mind of the average chemist aromatic molecules containing one or more nitrogen atoms. This view undoubtedly derives from the overwhelming biological and pharmaceutical importance of such entities as well as their wide distribution in nature. However, heterocycles can also be aliphatic and can contain, apart from nitrogen, other heteroatoms such a Read More

Organosilicon compounds are perhaps the most important inter-element compounds, as exemplified by disilanes and polysilanes. Similarly, ever since fullerene C60 became available in preparatively useful quantities, this new allotropic form of carbon has attracted much attention, particularly its chemical functionalization. The present review describes how these two disparate classes of compound can be induced to Read More

Marine sponges are shown to be abundant sources of bioactive peptides. Structurally they include linear peptides, peptide lactones, cyclic peptides, and depsipeptides, with number of residues ranging from two to 48. Some of them have highly modified structural features with nonproteinogenic amino acid or hydroxy acid residues, while others have those with minimal alterations from the common ribosomal peptides. The struct Read More

N,O-Disubstituted hydroxylamines (R1NHOR2 or NODHA), unlike the O-monosubstituted derivatives, have received little attention so far. However, they have recently become important as intermediates for synthesizing complex nitrogen-containing compounds, especially natural products and their analogues.The formation of NODHA by stereoselective reduction, nucleophile and radical additions provides access to acyclic, carb Read More

Quaternary salts of pyridine and related compounds are a topic of numerous reports. In the present review, eight chapters are devoted to selected examples of these compounds describing their syntheses, physicochemical properties and possible applications, along with their biological activities. The ninth chapter deals with the chemistry of viologens, while the tenth reviews selected work from our research group on be Read More