Current Organic Chemistry - Volume 7, Issue 6, 2003

The focus of this review is to simplify the role of acyl donor (P1) and the nucleophile (P'1) in an enzymatic reaction. The specificity of P1 and P'1 is described and arranged in order. In this review, the relationship between the amino acid and enzyme is linked to facilitate the selection of an enzyme to catalyze the synthesis of the desired peptides.

Epoxy alcohols are extremely versatile building blocks in organic synthesis, due to their general availability in both enantiomeric series. The preferred methods for the subsequent stereoselective attack of various nucleophiles (hydride, carbon nucleophiles, nitrogen nucleophiles, oxygen nucleophiles, halogen ions, etc.) in a regioselective fashion at C2 and C3 are reviewed. The application of some of these methods in the Read More

Sulfonate and sulfonamide are electron withdrawing activators for both vinyl and acetylenic units. These vinyl (acyclic and cyclic) and acetylenic sulfonates and sulfonamides are versatile dienophiles in inter- and intramolecular Diels-Alder reactions, as well as dipolarophiles in 1,3-dipolar cycloadditions. Asymmetric versions of these cycloaddition reactions are also known. Further manipulation of the cycloaddition products Read More

This article (the second of three parts) reviews the use of 1,3-dipolar cycloaddition reactions of nitrones and the closely related oximes in the construction of carbohydrate mimics. Preparation of isoxazoline and carbocyclic nucleosides, isoxazoline fused systems, polyhydroxylated and aminopolyhydroxylated carbocycles and azasugars, amino sugars, polyhydroxylated alkaloids of the pyrrolidine and indolizidine series is Read More