Current Organic Chemistry - Volume 24, Issue 5, 2020

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highli Read More

Amidoalkyl-2-naphthol is one of the vital synthetic intermediates which occupy an imperative position in medicinal chemistry due to its amazing biological, pharmacological as well as industrial and synthetic applications. Owing to its diverse pharmaceutical activities, hundreds of scientific literature are available, signifying the efficient synthesis of this intermediate using various catalysts. Most of these literature methods suf Read More

Natural products have received much attention due to their importance and application. Indolizidine, categorized as an alkaloid, has several biological activities. The synthesis of natural compounds such as indolizidines has attracted much attention from many chemists’ and researchers’ perspectives. There are many areas to be explored in this subject; that is why synthesizing indolizidine 209I and (±)-indolizidine 209B as Read More

1,2,3-triazoles are popular heterocycles employed in material sciences and medicinal chemistry as they show antiviral, antibacterial, anti-HIV, antitubercular, and antifungal activities. Triazoles are appealing due to their stability and interesting click chemistry properties. The Cu(I) catalyzed reaction between azides and alkynes affords the 1,4- disubstituted derivative exclusively becoming a useful synthetic tool. However, one Read More

Organic symmetric disulfides have been broadly studied in various fields such as synthetic intermediates for various organic transformations, agro-chemicals, biochemistry, pharmacological chemistry, industrial polymers, peptidomimetics, self-assembled monolayers (SAMs), etc. Owing to versatile applications, the search and development of efficient, environmentally friendly, mild and inexpensive methods for the preparati Read More