Current Organic Chemistry - Volume 24, Issue 23, 2020

4H-dithieno[3,2-b:2',3'-d]pyrrole has recently become a useful building block in the synthesis of donor-acceptor molecules with practical application in various organic technologies. The DTP molecule itself consists of a pyrrole ring with two fused thiophenes providing an alternative for the related dithieno[3,2-b:2′,3′-d]thiophene. Most notably, the significance of DTP-based low- and high-molecular weight species has increased in re Read More

The last decade has seen a huge growth in the construction of chiral systems to expand the scope of chiroptical applications. Dependence of chiroptical response on molecular conformation typically leads to low chiroptical intensities of chiral systems that feature several conformations in solution. In this respect, allenes were employed for the preparation of open and cyclic oligomers as well as molecular cages, presenting Read More

Owing to the growing demand for compelling antimicrobial agents, chalcones and their heterocyclic derivatives have engrossed prodigious attention of medicinal chemists as an effective clinical template for the synthesis of such agents on account of their structural diversity and molecular flexibility. Chalcones are considered as a fortunate scaffold in the field of both synthetic as well as natural product chemistry. Read More

Enzymatic kinetic resolution is one of the methods which allows for the synthesis of enantiomerically pure various active pharmaceutical ingredients. In contrast to chemical routes, enzymatic reactions have characteristics, including mild reaction conditions, a few byproducts, and relatively high activity of the used enzymes. β-adrenolytic drugs are widely used in the treatment of hypertension and cardiovascular dis Read More

Synthesis of 1,5-disubstituted tetrazoles by the cyclization of sodium azide with N(N),N'-di(tri)substituted carbamimidothioate is reported. Tetrazoles are obtained in good to excellent yield in the absence of a catalyst. All the compounds were characterized by NMR and HRMS analysis. Single crystal X-ray diffraction data of 1-(4-chlorophenyl)-4-(5-phenyl- 1H-tetrazol-1-yl)piperazine 5g is also provided. Further, these disubstitut Read More