Current Organic Chemistry - Volume 11, Issue 10, 2007

1,4-Dihydropyridines are of great chemical and pharmacological significance as evidenced from a chapter written by Drs Reddy and Chakravarty form Dr Reddy's Laboratories Ltd, Hyderabad, India. It is well-known that carbon nucleophiles are useful in organic synthesis in general and in heterocyclic synthesis in particular. In the final comprehensive chapter Professors Madkour and Elgazwy from Ain Shams University, Cair Read More

1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.

New developments in the utilities of some carbon nucleophiles in heterocyclic synthesis are reviewed. General synthetic routes based on the utilization of carbon nucleophiles of active methylene are discussed. The major methods and modifications are analyzed. Heterocycles are ubiquitous in all kind of compounds of interest, and among all the possible synthetic methods of achieving their introduction into a struct Read More

As the well-known soft ionization techniques, matrix assisted laser desorption/ionization (MALDI) - time of flight (TOF) mass spectrometry and electrospray ionization (ESI) MS are widely used in the investigative field of macromolecules including biomolecules and synthetic polymers since they were introduced in the late 1980s. Herein, emphasis is put on the application of MALDI-TOF MS and ESI MS on synthetic polymers b Read More

The acid-catalyzed alkene-aldehyde condensation, known as the Prins reaction, is reviewed. Lewis acids, organic acids and supported catalysts have been reported to assist both the Prins acyclic reaction and the Prins cyclization. Acetals and oxocarbenium ions (generated from aldehydes and alcohols) have been described as reacting systems in the Prins reaction. Prins cyclizations have been used to form mainly five- and Read More