Current Organic Chemistry - Volume 11, Issue 2, 2007

Carbon-carbon bond forming reactions are simple and direct methods for synthesizing the various skeletons and the diverse structures of organic compounds. Even 100 years after the discovery of the Grignard reaction, organomagnesium, organolithium, and organoaluminum remain popular for carbon-carbon bond formation reactions in modern organic chemistry. Moreover, asymmetric alkyl- or aryl-additions to carbonyl co Read More

In the early 1950s Witkop described in a series of papers that oxidation of indoles with a variety of oxidation reagents leads to the formation of quinolones. The mechanism of this reaction involves the oxidative cleavage of the 2,3- double bond of the indole moiety (Witkop-oxidation) followed by a Camps-cyclization forming the quinolone ring. Winterfeldt identified conditions which allow a one pot Witkop-oxidation/Camps-cycliz Read More

Over the last 30 years, the use of diazocarbonyl compounds has been a very fertile field for the development of new synthetic methods for constructing C-C bonds and heterocyclic rings. The reactions of the carbenoids, derived from the diazocarbonyls, offer exciting new strategies for the construction of complex target molecules due to the range of unusual transformations and cascade sequences which can be utilized Read More

Oligopyridines connected through the 2- and 6- positions have long been the subject of continuing interest because of their high ability to interact with metal ions and/or other molecules, and their transition-metal complexes have been intensely studied for decades because of their characteristic photophysical properties. However, relatively few have been known in regard to the photophysical and photo-functional pr Read More

Sulfonamide is an important functional group. Its cyclic version, sultam, has been successfully employed as a chiral auxiliary in controlling diastereoselectivities of numerous organic transformations. In this paper, the uses of chiral sultams that are not derived from camphor as chiral auxiliaries in asymmetric syntheses are reviewed.

The reactivators of acetylcholinesterase are very important components in the treatment of intoxications caused by organophosphate inhibitors such as tabun, sarin, soman, VX etc. and insecticides like echothiofat, metrifonat, chlorpyrifos etc. These inhibitors covalently bind on active site of mentioned enzyme and irreversibly inhibit its activity. The reactivator breaks the inhibitor-enzyme covalent bond and restores its activity. Read More