Current Organic Chemistry - Volume 11, Issue 5, 2007

This issue constitutes Part II of the first thematic issue of Bioorganic Chemistry published in Current Organic Chemistry. It contains three timely reviews that highlight three important subjects. Prof Toth with his co-workers describes the recent developments in synthetic chemistry of phosphopeptides. Proteomics of phosphoproteome is one of the most actively investigated fields of systems biology. Protein phosphoryl Read More

Protein phosphorylation is one of the most important post-translational events in cell regulation and signal transduction. Since the isolation of phosphorylated peptides from biological sources is usually not feasible, there is a need for efficient chemical phosphorylation methods to allow the study of the role of phosphorylation/dephosphorylation in biological processes. The recent developments in phosphopeptide chemistry (s Read More

This review reports on the synthesis of 7-deazapurine 2'-deoxyribonucleosides, including β-D- and β-Lenantiomers, fluoro derivatives, and 2',3'-dideoxyribonucleosides. It covers the various aspects of convergent nucleoside synthesis. Stereochemically defined α-D- and α-L-2-deoxy-3,5-di-O-(p-toluoyl)-erythro-pentofuranosyl chlorides as well as 3,5-di-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranosyl bromide were employed i Read More

Recent chemical approaches towards artificial restriction DNA cutters (ARCUT) are reviewed. New tools to cut either single-stranded DNA or double-stranded DNA at predetermined sites have been prepared. As molecular scissors, these cutters employ Ce(IV)/EDTA complex that preferentially hydrolyzes single-stranded DNA over double-stranded DNA. Hot-spots for site-selective scission are prepared at predetermined site with Read More

The synthesis of a series of asymmetrical tertiary alkyl ethers from the etherification of tertiary alkyl alcohols with corresponding alcohols was investigated. Ionic liquids (ILs) with Brønsted acidity, [BsMIm][HSO4] (1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate) and [BMIm][HSO4] (1-butyl-3-methylimidazolium hydrogen sulfate), were found to be suitable catalysts for the reactions. Tertiary alkyl ethers includi Read More

Bestatin (ubenimex) is a dipeptide that can treat a variety of diseases. Over the last thirty years synthetic chemists have developed an assortment of routes to optically pure (-)-Bestatin. Many strategies include the use of pure starting materials like sugars and amino acids. In addition, the utilization of chiral auxiliary groups have been implemented to achieve an increase in stereoselectivity and to simplify the purification pr Read More