Current Organic Chemistry - Volume 11, Issue 9, 2007

Nitrile ylides are of considerable interest both from a theoretical and a synthetic viewpoint. Both aspects are discussed in the first account contributed by Prof. S. Vazquez and his co-workers from the University of Barcelona, Spain. Hydrazonates can be converted to a wide variety of heterocycles as demonstrated by Prof. Shawali and Prof. Sherif from the University of Cairo, Egypt. Unnatural α-amino acids is an active Read More

The preparation, physical and spectroscopic properties, and applications to organic synthesis of nitrile ylides are reviewed.

The chemistry of esters of hydrazonoic acids has gained increased interest in both synthetic organic chemistry and biological fields. Since a large number of developments in the use of such esters, a review of such developments, covering the literature up to mid 2005, seems to be of considerable value. The present review presents their structural features, nomenclature, synthetic methods and chemical reactions. Th Read More

The synthesis of unnatural α-amino acids is an area of research that has gained a lot of attention in recent years. The availability of synthetic methods for novel unnatural αamino acid derivatives and related compounds will be a critical point in the de novo design of molecules that mimic the conformation of the natural, active peptides. These molecules (peptidomimetics) are designed to display high receptor affinity and s Read More

3-n-Butylphthalide (1) and its analogues, which are the main components in the volatile oil of celery as well as a wide range of umbelliferae and composite plants, have potential applications as hypotensive drugs because of their strong pharmacological activities, such as improving the microcirculatory system of man's brain, improving nervous function deficiency, antiasthma, anticonvulsion, inhibiting platelet aggregatio Read More