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image of Whether the Liver-to-Portal Vein Ratio is Applicable for Evaluating the European Society of Gastrointestinal and Abdominal Radiology Hepatobiliary Phase in Gd-EOB-DTPA-Enhanced MRI?
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Abstract

Purpose:

This study aimed to verify whether the Liver-to-portal Ratio (LPR) can assess the adequacy of the Hepatobiliary Phase (HBP) for patients with different liver functions.

Methods:

A total of 125 patients were prospectively enrolled in the study and graded into the non-cirrhosis group (45), Child-Pugh A group (40), and Child-Pugh B/C group (40). The LPR on HBP was calculated after eight HBPs were obtained within 5-40 minutes. The adequate HBP was determined according to the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus statement. The differences in LPR and lesions’ conspicuity between 10-min HBP and adequate HBP were analyzed by paired -test and Wilcoxon signed-rank test, respectively. The chi-square test was used to test the difference in proportion with LPR larger than 1.462 between 10-min HBP and adequate HBP.

Results:

The differences in LPR and lesions’ conspicuity between 10-min HBP and adequate HBP were significant in Child-Pugh A and Child-Pugh B/C groups ( < 0.05), except for the non-cirrhosis group ( > 0.05). The differences in proportion with LPR larger than 1.462 between 10-min HBP and adequate HBP were not statistically significant in all groups (all > 0.05).

Conclusion:

The adequate HBP obtained according to the 2016 ESGAR consensus statement could provide larger LPR and better lesions’ conspicuity than 10-min HBP, especially for cirrhotic patients; however, the efficacy of using an LPR cutoff of 1.462 as the standard of the adequate HBP may be compromised in patients with cirrhosis.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-10-02
2024-11-26

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References

  1. Hamm B. Staks T. Mühler A. Bollow M. Taupitz M. Frenzel T. Wolf K.J. Weinmann H.J. Lange L. Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: Safety, pharmacokinetics, and MR imaging. Radiology 1995 195 3 785 792 10.1148/radiology.195.3.7754011 7754011
    [Google Scholar]
  2. Vogl T.J. Kümmel S. Hammerstingl R. Schellenbeck M. Schumacher G. Balzer T. Schwarz W. Müller P.K. Bechstein W.O. Mack M.G. Söllner O. Felix R. Liver tumors: Comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 1996 200 1 59 67 10.1148/radiology.200.1.8657946 8657946
    [Google Scholar]
  3. Akimoto S. Mori H. Fujii T. Furuya K. Optimal scan timing for Gd-EOB-DTPA enhanced liver dynamic MR imaging. Nippon Hoshasen Gijutsu Gakkai Zasshi 2009 65 5 626 630 10.6009/jjrt.65.626
    [Google Scholar]
  4. Dermot M. Magnetic resonance imaging of the liver: Consensus statement from the 1st international primovist user meeting. Eur Radiol Suppl. 2008 18 Suppl 4 849 864 10.1007/s10406‑008‑0010‑1.
    [Google Scholar]
  5. Kitao A. Matsui O. Yoneda N. Kozaka K. Shinmura R. Koda W. Kobayashi S. Gabata T. Zen Y. Yamashita T. Kaneko S. Nakanuma Y. The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: Correlation with gadoxetic acid enhanced MR imaging. Eur. Radiol. 2011 21 10 2056 2066 10.1007/s00330‑011‑2165‑8 21626360
    [Google Scholar]
  6. Zhou X. Long L. Mo Z. Li Y. OATP1B3 expression in hepatocellular carcinoma correlates with intralesional Gd-EOB-DTPA uptake and signal intensity on Gd-EOB-DTPA-enhanced MRI. Cancer Manag. Res. 2021 13 1169 1177 10.2147/CMAR.S292197 33603462
    [Google Scholar]
  7. Sofue K. Tsurusaki M. Tokue H. Arai Y. Sugimura K. Gd-EOB-DTPA-enhanced 3.0 T MR imaging: Quantitative and qualitative comparison of hepatocyte-phase images obtained 10 min and 20 min after injection for the detection of liver metastases from colorectal carcinoma. Eur. Radiol. 2011 21 11 2336 2343 10.1007/s00330‑011‑2197‑0 21748389
    [Google Scholar]
  8. Nakamura S. Awai K. Utsunomiya D. Namimoto T. Nakaura T. Morita K. Yamashita Y. Chronological evaluation of liver enhancement in patients with chronic liver disease at Gd-EOB-DTPA-enhanced 3-T MR imaging: Does liver function correlate with enhancement? Jpn. J. Radiol. 2012 30 1 25 33 10.1007/s11604‑011‑0003‑1 22160649
    [Google Scholar]
  9. van Kessel C.S. Veldhuis W.B. van den Bosch M.A.A.J. van Leeuwen M.S. MR liver imaging with Gd-EOB-DTPA: A delay time of 10 minutes is sufficient for lesion characterisation. Eur. Radiol. 2012 22 10 2153 2160 10.1007/s00330‑012‑2486‑2 22645040
    [Google Scholar]
  10. Esterson Y.B. Flusberg M. Oh S. Mazzariol F. Rozenblit A.M. Chernyak V. Improved parenchymal liver enhancement with extended delay on Gd-EOB-DTPA-enhanced MRI in patients with parenchymal liver disease: Associated clinical and imaging factors. Clin. Radiol. 2015 70 7 723 729 10.1016/j.crad.2015.03.005 25921617
    [Google Scholar]
  11. Liang M. Zhao J. Xie B. Li C. Yin X. Cheng L. Wang J. Zhang L. MR liver imaging with Gd-EOB-DTPA: The need for different delay times of the hepatobiliary phase in patients with different liver function. Eur. J. Radiol. 2016 85 3 546 552 10.1016/j.ejrad.2015.12.015 26860666
    [Google Scholar]
  12. Wu J.W. Yu Y.C. Qu X.L. Zhang Y. Gao H. Optimization of hepatobiliary phase delay time of Gd-EOB-DTPA-enhanced magnetic resonance imaging for identification of hepatocellular carcinoma in patients with cirrhosis of different degrees of severity. World J. Gastroenterol. 2018 24 3 415 423 10.3748/wjg.v24.i3.415 29391764
    [Google Scholar]
  13. Motosugi U. Ichikawa T. Tominaga L. Sou H. Sano K. Ichikawa S. Araki T. Delay before the hepatocyte phase of Gd-EOB-DTPA-enhanced MR imaging: Is it possible to shorten the examination time? Eur. Radiol. 2009 19 11 2623 2629 10.1007/s00330‑009‑1467‑6 19471935
    [Google Scholar]
  14. Bashir M.R. Breault S.R. Braun R. Do R.K. Nelson R.C. Reeder S.B. Optimal timing and diagnostic adequacy of hepatocyte phase imaging with gadoxetate-enhanced liver MRI. Acad. Radiol. 2014 21 6 726 732 10.1016/j.acra.2014.02.005 24717550
    [Google Scholar]
  15. Takatsu Y. Kobayashi S. Miyati T. Shiozaki T. A novel method for evaluating enhancement using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid in the hepatobiliary phase of magnetic resonance imaging. Clin. Imaging 2016 40 6 1112 1117 10.1016/j.clinimag.2016.07.001 27450444
    [Google Scholar]
  16. Mori Y. Motosugi U. Shimizu T. Ichikawa S. Kromrey M.L. Onishi H. Predicting patients with insufficient liver enhancement in the hepatobiliary phase before the injection of gadoxetic acid: A practical approach using the Bayesian method. J. Magn. Reson. Imaging 2020 51 1 62 69 10.1002/jmri.26760 31016840
    [Google Scholar]
  17. Takatsu Y. Nakamura M. Kobayashi S. Miyati T. Prediction of sufficient liver enhancement on the gadoxetate disodium-enhanced hepatobiliary phase imaging using transitional phase images and Albumin–bilirubin grade. Magn. Reson. Med. Sci. 2021 20 2 152 159 10.2463/mrms.mp.2020‑0050 32461506
    [Google Scholar]
  18. Takatsu Y. Nakamura M. Shiozaki T. Narukami S. Yoshimaru D. Miyati T. Kobayashi S. Assessment of the cut-off value of quantitative liver–portal vein contrast ratio in the hepatobiliary phase of liver MRI. Clin. Radiol. 2021 76 7 551.e17 551.e24 10.1016/j.crad.2021.03.015 33902888
    [Google Scholar]
  19. Neri E. Bali M.A. Ba-Ssalamah A. Boraschi P. Brancatelli G. Alves F.C. Grazioli L. Helmberger T. Lee J.M. Manfredi R. Martì-Bonmatì L. Matos C. Merkle E.M. Op De Beeck B. Schima W. Skehan S. Vilgrain V. Zech C. Bartolozzi C. ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents. Eur. Radiol. 2016 26 4 921 931 10.1007/s00330‑015‑3900‑3 26194455
    [Google Scholar]
  20. Ye X. Liu X. Song D. Zhang X. Zhu B. Wei L. Pei X. Wu J. Lou T. Zhao W. Estimating glomerular filtration rate by serum creatinine or/and cystatin C equations: An analysis of multi‐centre Chinese subjects. Nephrology (Carlton) 2016 21 5 372 378 10.1111/nep.12636 26427030
    [Google Scholar]
  21. Kato N. Yokawa T. Tamura A. Heshiki A. Ebert W. Weinmann H.J. Gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid interaction with clinical drugs in rats. Invest. Radiol. 2002 37 12 680 684 10.1097/00004424‑200212000‑00007 12447001
    [Google Scholar]
  22. Vavricka S.R. Van Montfoort J. Ha H.R. Meier P.J. Fattinger K. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 2002 36 1 164 172 10.1053/jhep.2002.34133 12085361
    [Google Scholar]
  23. Cruite I. Schroeder M. Merkle E.M. Sirlin C.B. Gadoxetate disodium-enhanced MRI of the liver: Part 2, protocol optimization and lesion appearance in the cirrhotic liver. AJR Am. J. Roentgenol. 2010 195 1 29 41 10.2214/AJR.10.4538 20566795
    [Google Scholar]
  24. Ringe K.I. Husarik D.B. Sirlin C.B. Merkle E.M. Gadoxetate disodium-enhanced MRI of the liver: Part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR Am. J. Roentgenol. 2010 195 1 13 28 10.2214/AJR.10.4392 20566794
    [Google Scholar]
  25. EASL clinical practice guidelines on the management of benign liver tumours. J. Hepatol. 2016 65 2 386 398 10.1016/j.jhep.2016.04.001 27085809
    [Google Scholar]
  26. Zech C.J. Ba-Ssalamah A. Berg T. Chandarana H. Chau G.Y. Grazioli L. Kim M.J. Lee J.M. Merkle E.M. Murakami T. Ricke J. B Sirlin C. Song B. Taouli B. Yoshimitsu K. Koh D.M. Consensus report from the 8th International Forum for liver magnetic resonance imaging. Eur. Radiol. 2020 30 1 370 382 10.1007/s00330‑019‑06369‑4 31385048
    [Google Scholar]
  27. Koh D.M. Ba-Ssalamah A. Brancatelli G. Fananapazir G. Fiel M.I. Goshima S. Ju S.H. Kartalis N. Kudo M. Lee J.M. Murakami T. Seidensticker M. Sirlin C.B. Tan C.H. Wang J. Yoon J.H. Zeng M. Zhou J. Taouli B. Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging. Eur. Radiol. 2021 31 8 5615 5628 10.1007/s00330‑020‑07637‑4 33523304
    [Google Scholar]
  28. Takatsu Y. Nakamura M. Kobayashi S. Miyati T. Visual criterion for evaluating hepatobiliary phase image acquisition of gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid-enhanced MRI. Clin. Radiol. 2018 73 8 760.e1 760.e6 10.1016/j.crad.2018.04.001 29724434
    [Google Scholar]
/content/journals/cmir/10.2174/0115734056318603240910115315
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Whether the Liver-to-Portal Vein Ratio is Applicable for Evaluating the European Society of Gastrointestinal and Abdominal Radiology Hepatobiliary Phase in Gd-EOB-DTPA-Enhanced MRI?
Bentham Science Publishers ; https://doi.org/10.2174/0115734056318603240910115315
/content/journals/cmir/10.2174/0115734056318603240910115315
/content/journals/cmir/10.2174/0115734056318603240910115315
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  • Article Type:     Research Article
Keywords: Magnetic resonance imaging ; Liver-to-portal vein ratio ; Gadoxetic acid disodium ; Hepatobiliary phase

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