Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medical Imaging
  4. Volume 20, Issue 1
  5. Article
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format pdf download PDF
side by side viewer icon HTML

Abstract

Introduction

Angiomatoid fibrous histiocytoma (AFH) is a borderline tumor usually affecting the the children or young adults. 18F-Fluorodexoyglucose (FDG) positron emission tomography/computed tomography (PET/CT) investigations of pulmonary AFH are rare, and there are currently no reports of intense FDG uptake in AFH.

Case Report

We report an AFH that occurred in the lung of a 57-year-old woman. She presented with paroxysmal cough and occasional bloodshot sputum. 18F-FDG PET/CT revealed a right parahilar nodule with intense FDG-avidity, middle lobe atelectasis, and several bilateral axillary lymph nodes with mild hypermetabolic activity. This patient underwent a right middle lobe lobectomy video-assisted thoracoscopy. Histopathologically, the diagnosis was pulmonary AFH. She had an uneventful postoperative course, and the bilateral axillary lymph nodes regressed during postoperative follow-up.

Conclusions

The clinical presentation and image findings of patients with primary pulmonary AFH may be potential diagnosis pitfalls. The diagnosis of lymph nodes or distant metastases should be approached with caution. To avoid misdiagnosis, biopsy with histological examination and immunohistochemichal staining should be performed as early as possible.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056290944240408051730
2024-01-01
2025-06-30

  • From This Site

    /content/journals/cmir/10.2174/0115734056290944240408051730
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. QiangG. HuangW. LiangC. XuR. YanJ. XuY. WangY. DaJ. ShiB. GuoY. LiuD. Association between histopathological subtype, 18F-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in lung adenocarcinoma.Oncol. Lett.20161131769177710.3892/ol.2016.415426998075
     [Google Scholar]
  2. GeadasC. Acuna-VillaordunaC. MercierG. KleinmanM.B. HorsburghC.R.Jr EllnerJ.J. JacobsonK.R. FDG-PET/CT activity leads to the diagnosis of unsuspected TB: A retrospective study.BMC Res. Notes201811146410.1186/s13104‑018‑3564‑630001743
     [Google Scholar]
  3. BohelayG. KlugerN. BattistellaM. Biaggi-FrassatiA. PlantierF. HarraudeauA. AvrilM.F. PedeutourF. FraitagS. Angiomatoid fibrous histiocytoma in children: 6 cases.Ann. Dermatol. Venereol.20151421054154810.1016/j.annder.2015.07.00726363999
     [Google Scholar]
  4. RaniD. GuptaA. GuptaA. RastogiK. Cytological diagnosis of angiomatoid fibrous histiocytoma: Report of a case and review of literature.Diagn. Cytopathol.2021491E36E3910.1002/dc.2457032749779
     [Google Scholar]
  5. ColangeliM. RimondiE. SpinnatoP. DonatiD.M. ManfriniM. Difficult diagnosis of angiomatoid fibrous histiocytoma of the leg mimicking a benign condition.J. Radiol. Case Rep.2019134384510.3941/jrcr.v13i4.341431565180
     [Google Scholar]
  6. WangZ. ZhangL. RenL. LiuD. DuJ. ZhangM. LouG. SongY. WangY. WuC. HanG. Distinct clinicopathological features of pulmonary primary angiomatoid fibrous histiocytoma: A report of four new cases and review of the literature.Thorac. Cancer202112331432310.1111/1759‑7714.1372733314685
     [Google Scholar]
  7. SloanE.A. ChiangJ. Villanueva-MeyerJ.E. AlexandrescuS. EschbacherJ.M. WangW. MafraM. Ud DinN. Carr-BoydE. WatsonM. PunsoniM. OviedoA. GilaniA. Kleinschmidt-DeMastersB.K. CossD.J. LopesM.B. RaffelC. BergerM.S. ChangS.M. ReddyA. RamaniB. FerrisS.P. LeeJ.C. HofmannJ.W. ChoS.J. HorvaiA.E. PekmezciM. TihanT. BollenA.W. RodriguezF.J. EllisonD.W. PerryA. SolomonD.A. Intracranial mesenchymal tumor with FET-CREB fusion—A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms.Brain Pathol.2021314e1291810.1111/bpa.1291833141488
     [Google Scholar]
  8. SpatzM. NussbaumE.S. LyonsL. GreenbergS. KallmesK.M. NussbaumL.A. Primary intracranial angiomatoid fibrous histiocytoma: A case report and literature review.Br. J. Neurosurg.202135223323510.1080/02688697.2018.145182329540076
     [Google Scholar]
  9. RenL. GuoS.P. ZhouX.G. ChanJ.K.C. Angiomatoid fibrous histiocytoma: First report of primary pulmonary origin.Am. J. Surg. Pathol.200933101570157410.1097/PAS.0b013e3181b20e6419654501
     [Google Scholar]
  10. MaherO.M. PrietoV.G. StewartJ. HerzogC.E. Characterization of metastatic angiomatoid fibrous histiocytoma.J. Pediatr. Hematol. Oncol.2015374e268e27110.1097/MPH.000000000000031325757019
     [Google Scholar]
  11. UlanerG.A. HealeyJ.H. AthanasianE.A. Pathologically benign lymph nodes can mimic malignancy on imaging in patients with angiomatoid fibrous histiocytoma.Clin. Orthop. Relat. Res.201747592274227910.1007/s11999‑017‑5388‑428536856
     [Google Scholar]
  12. TayCK KohMS TakanoA AubryMC SukovWR FolpeAL Primary angiomatoid fibrous histiocytoma of the lung with mediastinal lymph node metastasis.Hum Pathol20165813413710.1016/j.humpath.2016.07.022
     [Google Scholar]
  13. BoumaW. KoningK.J. SuurmeijerA.J.H. SlebosD.J. MarianiM.A. KlinkenbergT.J. Hybrid bronchoscopic and surgical resection of endotracheal angiomatoid fibrous histiocytoma.J. Cardiothorac. Surg.20191414810.1186/s13019‑019‑0861‑730819218
     [Google Scholar]
  14. ChoiB.H. YoonS.H. LeeS. JoK.S. SongH.S. AnY.S. YoonJ.K. LeeS.J. Primary malignant fibrous histiocytoma in mediastinum: Imaging with 18F-FDG PET/CT.Nucl. Med. Mol. Imaging201246430430710.1007/s13139‑012‑0157‑524900079
     [Google Scholar]
  15. SaitoK. KobayashiE. YoshidaA. ArakiY. KubotaD. TanzawaY. KawaiA. YanagawaT. TakagishiK. ChumanH. Angiomatoid fibrous histiocytoma: A series of seven cases including genetically confirmed aggressive cases and a literature review.BMC Musculoskelet. Disord.20171813110.1186/s12891‑017‑1390‑y28114920
     [Google Scholar]
  16. DawN.C. BillupsC.A. PappoA.S. JenkinsJ.J. MahmoudH.H. KrasinM.J. RaoB.N. Malignant fibrous histiocytoma and other fibrohistiocytic tumors in pediatric patients.Cancer200397112839284710.1002/cncr.1138412767098
     [Google Scholar]
  17. FletcherC.D.M. The evolving classification of soft tissue tumours an update based on the new 2013 WHO classification.Histopathology201464121110.1111/his.1226724164390
     [Google Scholar]
  18. YoshidaA. WakaiS. RyoE. MiyataK. MiyazawaM. YoshidaK. MotoiT. OgawaC. IwataS. KobayashiE. WatanabeS. KawaiA. MoriT. Expanding the phenotypic spectrum of mesenchymal tumors harboring the EWSR1-CREM Fusion.Am. J. Surg. Pathol.201943121622163010.1097/PAS.000000000000133131305268
     [Google Scholar]
  19. ThwayK. FisherC. Angiomatoid fibrous histiocytoma: The current status of pathology and genetics.Arch. Pathol. Lab. Med.2015139567468210.5858/arpa.2014‑0234‑RA25927151
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056290944240408051730
Loading
Clinical Presentations and Intense FDG-avidity in Pulmonary Angiomatoid Fibrous Histiocytoma with Potential Diagnostic Pitfalls: A Case Report and Literature Review
Curr. Med. Imaging 20, e15734056290944 (2024); https://doi.org/10.2174/0115734056290944240408051730
/content/journals/cmir/10.2174/0115734056290944240408051730
/content/journals/cmir/10.2174/0115734056290944240408051730
Loading

Data & Media loading...

Supplements

Supplementary material is available on the Publisher’s website.

file format download Download

  • Article Type:     Case Report
Keyword(s): 18F-fluorodexoyglucose; Case report; Clinical presentation; FDG-avidity; Positron emission tomography/computed tomography; Pulmonary angiomatoid fibrous histiocytoma

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test