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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Evidence of the association between obesity and renal cell carcinoma progression is contradictory. The effects of renal cell carcinoma on fat distribution are still unknown.

Objective

The goal of this study was to determine the ability of various forms of fat deposition to predict the Fuhrman nuclear grade of clear cell renal cell carcinoma [ccRCC].

Methods

This retrospective study included 320 patients with pathologically proven ccRCC [215 men and 105 women; 263 low-grade ccRCC and 57 high-grade ccRCC]. Based on computed tomography scans, adipose tissue in various body regions was classified into the perirenal fat area [PFA], visceral fat area [VFA], total fat area [TFA], subcutaneous fat area [SFA], and hepatic steatosis [HS]. Subsequently, the relative VFA [rVFA] was computed. Age, sex, body mass index, and maximal tumor diameter were also regarded as clinical factors. Univariate and multivariate logistic regression studies were conducted to evaluate whether there was an association between body fat composition and the Fuhrman classification and whether it was related to gender.

Results

After correcting for age, males with low-grade ccRCC exhibited higher TFA [257.6 . 203.0, p = 0.002], VFA [151.6 .115.5, p = 0.007], SFA [106.0 . 87.5, p = 0.015], PFA [55.1 . 30.4, p < 0.001], and HS [18% . 0%, p = 0.031] than those with high-grade ccRCC. There was no significant difference among rVFA in males. In females, there was no significant difference in any of the parameters. VFA and PFA remained independent predictors for high-grade ccRCC in males in both the monovariate [VFA: odds ratio [OR] 0.992, 95% confidence interval [CI] 0.987–0.997, p = 0.004; PFA: OR 0.949, 95% CI 0.930–0.970, p < 0.001] and multivariate [VFA: OR 1.028, 95% CI 1.001–1.074, p < 0.001; PFA: OR 0.878, 95% CI 0.833–0.926, p < 0.001] models.

Conclusion

Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an independent predictor of high-grade ccRCC in male patients.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-06-26

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/content/journals/cmir/10.2174/0115734056295913240514020603
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Can Gender-Specific Renal and Visceral Fat Evaluated by CT Predict the Fuhrman Nuclear Classification of Clear Cell Renal Cell Carcinoma?
Curr. Med. Imaging 20, e15734056295913 (2024); https://doi.org/10.2174/0115734056295913240514020603
/content/journals/cmir/10.2174/0115734056295913240514020603
/content/journals/cmir/10.2174/0115734056295913240514020603
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  • Article Type:     Research Article
Keyword(s): Abdominal; BMI; Clear renal cell carcinoma; Computed tomography; Neoplasm grading; Obesity; Visceral fat

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