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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background:

Carotid duplex ultrasonography (DUS) is the primary screening tool for carotid artery stenosis, but has low reliability. MHR, which is the ratio of monocytes to high-density lipoprotein cholesterol (HDL-C), can be a marker for the degree and distribution of extracranial and intracranial atherosclerotic stenosis.

Objective:

We determined the diagnostic value of DUS+MHR for internal carotid artery (ICA) stenosis.

Methods:

We divided 273 hospitalized patients into non-stenosis (<50%) and ICA stenosis (≥50%) groups based on Digital Subtraction Angiography (DSA). We determined the peak systolic velocity (PSV) in the ICA on DUS, calculated the MHR, and investigated their relationship with ICA stenosis.

Results:

On DSA, 34.1% (93/273) patients had moderate-to-severe ICA stenosis. DUS and DSA showed low concordance for detecting ICA stenosis (kappa = 0.390). With increasing age, the incidence of moderate-to-severe ICA stenosis increased. PSV, monocyte count, and MHR were significantly greater in the stenosis group than in the non-stenosis group ( < 0.001), while the HDL-C level was significantly lower ( = 0.001). PSV (OR: 1.020, 95% CI: 1.011–1.029, < 0.001) and MHR (OR: 5.662, 95% CI: 1.945–16.482, = 0.002) were independent risk factors for ICA stenosis. The area under the receiver operating characteristic curve of PSV+MHR (0.819) was significantly higher than that of PSV or MHR alone (77.42% sensitivity, = 0.0207; 73.89% specificity, = 0.0032).

Conclusion:

The combination of ICA PSV on DUS and MHR is better than PSV alone at identifying ICA stenosis and is well-suited to screen high-risk patients.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-04-18
2025-06-26

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/content/journals/cmir/10.2174/0115734056289735240409083434
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Role of Carotid Ultrasonography Combined with Monocyte/HDL Ratio in Internal Carotid Artery Stenosis
Curr. Med. Imaging 20, e15734056289735 (2024); https://doi.org/10.2174/0115734056289735240409083434
/content/journals/cmir/10.2174/0115734056289735240409083434
/content/journals/cmir/10.2174/0115734056289735240409083434
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  • Article Type:     Research Article
Keyword(s): Carotid duplex ultrasonography (DUS); Digital subtraction angiography (DSA); High-risk patients; Internal carotid artery (ICA) stenosis; MHR; PSV

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