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2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603

Abstract

Background

The metastasis of primary breast invasive lobular carcinoma to the gastrointestinal tract and skin is a rare phenomenon, with the simultaneous occurrence of both transfers being more uncommon.

Case Presentation

This article reports a case of a patient with hormone receptor-positive, HER2-negative breast invasive lobular carcinoma with gastrointestinal tract and skin metastases. The patient was assessed by a second-look ultrasound and diagnosed by subsequent ultrasound-guided needle biopsy. Following endocrine therapy, a favorable effect was observed, with significant regression of the primary breast lesion, cutaneous metastases, and gastrointestinal metastases.

Conclusion

Patients with breast invasive lobular carcinoma should be alert to the possibility of breast cancer metastasis, even if there are no obvious symptoms or signs, when they encounter rapidly progressive cutaneous nodules or plaques, or if they possess gastrointestinal abnormalities. For patients with negative breast ultrasonography for the first time, after combining mammography, Contrast-enhanced Spectral Mammography (CESM) or Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) examinations, if breast cancer is highly suspected, second-look ultrasound is particularly crucial at this juncture, which is the key prerequisite for breast needle biopsy and obtaining the gold standard of pathology.

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-07-11
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References

  1. SungH. FerlayJ. SiegelR.L. LaversanneM. SoerjomataramI. JemalA. BrayF. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J. Clin.202171320924910.3322/caac.2166033538338
    [Google Scholar]
  2. NarbeU. BendahlP.O. AaltonenK. FernöM. ForsareC. JørgensenC.L.T. LarssonA.M. RydénL. The distribution of circulating tumor cells is different in metastatic lobular compared to ductal carcinoma of the breast—long-term prognostic significance.Cells202097171810.3390/cells907171832709042
    [Google Scholar]
  3. ZhuS. WardB.M. YuJ. Matthew-OnabanjoA.N. JanusisJ. HsiehC.C. TomaszewiczK. HutchinsonL. ZhuL.J. KandilD. ShawL.M. IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma.JCI Insight201838e9739810.1172/jci.insight.9739829669935
    [Google Scholar]
  4. HuS.C.S. ChenG.S. WuC.S. ChaiC.Y. ChenW.T. LanC.C.E. Rates of cutaneous metastases from different internal malignancies: Experience from a Taiwanese medical center.J. Am. Acad. Dermatol.200960337938710.1016/j.jaad.2008.10.00719056145
    [Google Scholar]
  5. McLemoreE.C. PockajB.A. ReynoldsC. GrayR.J. HernandezJ.L. GrantC.S. DonohueJ.H. Breast cancer: Presentation and intervention in women with gastrointestinal metastasis and carcinomatosis.Ann. Surg. Oncol.2005121188689410.1245/ASO.2005.03.03016177864
    [Google Scholar]
  6. TaalB.G. PeterseH. BootH. Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma.Cancer200089112214222110.1002/1097‑0142(20001201)89:11<2214::AID‑CNCR9>3.0.CO;2‑D11147591
    [Google Scholar]
  7. AbidA. MoffaC. MongaD.K. Breast cancer metastasis to the GI tract may mimic primary gastric cancer.J. Clin. Oncol.2013317e106e10710.1200/JCO.2012.44.639323319694
    [Google Scholar]
  8. JonesG.E. StraussD.C. ForshawM.J. DeereH. MahedevaU. MasonR.C. Breast cancer metastasis to the stomach may mimic primary gastric cancer: report of two cases and review of literature.World J. Surg. Oncol.2007517510.1186/1477‑7819‑5‑7517620117
    [Google Scholar]
  9. KoikeK. KitaharaK. HigakiM. UrataM. YamazakiF. NoshiroH. Clinicopathological features of gastric metastasis from breast cancer in three cases.Breast Cancer201421562963410.1007/s12282‑011‑0284‑321779814
    [Google Scholar]
  10. TaalB.G. den Hartog JagerF.C.A. SteinmetzR. PeterseH. The spectrum of gastrointestinal metastases of breast carcinoma: I. Stomach.Gastrointest. Endosc.199238213013510.1016/S0016‑5107(92)70377‑01568608
    [Google Scholar]
  11. BatesT. Illustrated. 1996. Philadelphia, pennsylvania.British Journal of SurgeryW B. Saunders1997844588610
    [Google Scholar]
  12. KreckeK.N. GisvoldJ.J. Invasive lobular carcinoma of the breast: Mammographic findings and extent of disease at diagnosis in 184 patients.AJR Am. J. Roentgenol.1993161595796010.2214/ajr.161.5.82736348273634
    [Google Scholar]
  13. BrkljačićB. DivjakE. Tomasović-LončarićČ. TešićV. IvanacG. Shear-wave sonoelastographic features of invasive lobular breast cancers.Croat. Med. J.2016571425010.3325/cmj.2016.57.4226935613
    [Google Scholar]
  14. WilkinsonL. ThomasV. SharmaN. Microcalcification on mammography: Approaches to interpretation and biopsy.Br. J. Radiol.20179010692016059410.1259/bjr.2016059427648482
    [Google Scholar]
  15. JamesJ.J. TennantS.L. Contrast-enhanced spectral mammography (CESM).Clin. Radiol.201873871572310.1016/j.crad.2018.05.00529937340
    [Google Scholar]
  16. RichterV. HattermanV. PreibschH. BahrsS.D. HahnM. NikolaouK. WiesingerB. Contrast-enhanced spectral mammography in patients with MRI contraindications.Acta Radiol.201859779880510.1177/028418511773556129058963
    [Google Scholar]
  17. XingD. LvY. SunB. XieH. DongJ. HaoC. ChenQ. ChiX. Diagnostic value of contrast-enhanced spectral mammography in comparison to magnetic resonance imaging in breast lesions.J. Comput. Assist. Tomogr.201943224525110.1097/RCT.000000000000083230531546
    [Google Scholar]
  18. HuangC. The points and difficulties of ultrasonography diagnosis for atypical breast cancer.J. Clin. Surg.2021293218221
    [Google Scholar]
  19. MaL. QinJ. KongL. ZhaoJ. XiaoM. WangH. ZhangJ. JiangY. LiJ. LiuH. ZhuQ. Can pre-biopsy second-look breast ultrasound affect clinical management? experience from a single tertiary hospital.Front. Oncol.20221290175710.3389/fonc.2022.90175735712464
    [Google Scholar]
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