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  3. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)
  4. Volume 22, Issue 2
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Volume 22, Issue 2
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182

Abstract

Introduction

Hypoglycemia and anemia are associated with diabetes mellitus. Medicinal plants and orthodox drugs have been used for the management of this disease. This study aimed to validate the ethnomedical claims of Linn. leaf extract in reducing hyperglycemia and hematological potentials in alloxan-induced diabetic rats and to identify likely antidiabetic compounds.

Materials and Methods

Ultra-high-performance liquid chromatography was used to identify the various phytochemical constituents. Male Wistar rats were randomly divided into five groups containing 6 rats per group. Group 1 (control) received 0.2 ml/kg of distilled water, group 2 received 130 mg/kg of aqueous extract, groups 3-5 were diabetic and received 0.2 ml/g distilled water, 130 mg/kg extract and 0.75 IU/kg insulin respectively for 14 days. Hematological parameters were measured and an oral glucose tolerance test was carried out using 2 g/kg body weight glucose. A histological analysis of the pancreas was done.

Results

Twenty-five compounds identified as flavonoids, phenolic acids, tannins, and triterpenoids were detected. The blood glucose levels were significantly ( <0.05) elevated in DM groups but were significantly ( <0.05) reduced following leaves extract to DM groups. There was s significant ( <0.05) increase in insulin levels improved hematological parameters (RBC, WBC, and platelets), and increased islet population.

Conclusion

These results suggest that extract has hypoglycemic, insulinogenic, and hematopoietic potentials in diabetic condition and offer protection to the pancreas which could be attributed to the phytochemical constituents thereby justifying its use in traditional therapy.

© 2024 Bentham Science Publishers
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2024-06-01
2025-05-22

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/content/journals/chamc/10.2174/1871525721666230526152917
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Identification of Phytochemicals and Assessment of Hypoglycemic and Haematological Potentials of Terminalia catappa Linn leaf Extract in Alloxan-induced Diabetic Wistar Rats
Cardiovasc. Hematol. Agents Med. Chem. 22, 139 (2024); https://doi.org/10.2174/1871525721666230526152917
/content/journals/chamc/10.2174/1871525721666230526152917
/content/journals/chamc/10.2174/1871525721666230526152917
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  • Article Type:     Research Article
Keyword(s): Glucose; hematology; insulin; pancreas; phytochemistry; Terminalia catappa

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