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  3. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)
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Volume 22, Issue 2
  • ISSN: 1871-5257
  • E-ISSN: 1875-6182
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Abstract

Background

Plants have been used for ages in traditional medicine, and it is exciting to perceive how recent research has recognized the bioactive compounds liable for their beneficial effects. Green synthesis of metal nanoparticles is a hastily emergent research area in nanotechnology. This study describes the synthesis of silver nanoparticles (AgNPs) using and leaf extract and its thrombolytic activity.

Objective

The aim of the study was to determine the clot lysis activity of and synthesized silver nanoparticles.

Methods

Leaves of and were collected. Methanolic extraction of the plant sample was done through a Soxhlet extractor. The methanolic extract obtained from both the leaves was subjected to GC-MS analysis. The synthesized NPs from leaf extracts were monitored for analysis, where the typical X-ray diffraction pattern and its diffraction peaks were identified. 3D image of the NPs was analysed by Atomic Force Microscopy. The surface charge of nanoparticles was identified by Zeta potential. The Clot lysis activity of and synthesized silver nanoparticles were analysed by the modified Holmstorm method.

Results

The thrombolytic property of the methanolic extract of plants showed clot lysis activity at 2.5 mg/mL with 45.99% activity, and extract with 66.56% activity. The nanoparticles (Nps) from showed clot lysis activity at 2.5 mg/mL with 58.29% activity, and NPs from with 54.04% activity. in GC-MS exhibited 3 peaks, whereas extract showed five peaks with notable bioactive compounds.

Conclusion

These NPs were further used for biomedical applications after being fixed by an organic encapsulation agent. The present research reveals the usefulness of and for the environmentally friendly manufacture of silver nanoparticles.

© 2024 Bentham Science Publishers
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2024-06-01
2024-11-26

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Green Synthesis of Silver Nanoparticles using Coriandrum sativum and Murraya koenigii Leaf Extract and its Thrombolytic Activity
Cardiovasc. Hematol. Agents Med. Chem. 22, 230 (2024); https://doi.org/10.2174/0118715257279159240118050207
/content/journals/chamc/10.2174/0118715257279159240118050207
/content/journals/chamc/10.2174/0118715257279159240118050207
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  • Article Type:     Research Article
Keyword(s): AgNPs; Coriandrum sativum; Murraya koenigii; nanoparticles (NPs); thrombolytic activity; XRD; zeta potential

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