Current Drug Therapy - Volume 7, Issue 4, 2012

This review focuses on the recent developments and future trends dealing with its modifications, encompassing the different grades of polymethacrylates polymers based formulations. The last three decades of pioneering works explain it as a new functional material of high potential value in novel drug delivery. Polymethacrylates are synthetic cationic and anionic copolymers of dimethylaminoethyl methacryl Read More

Chordoma is a rare type of tumor of the skeletal system that can occur anywhere along the spine, from the base of the skull to the tailbone. Chordoma is a slowly growing primary tumor that arise from an intra-osseous remnant of notochordal cells. These neoplasms typically occur in the axial skeleton; the most common location is the sacrococcygeal region followed by skull base and spine. Chordomas typically occur in ad Read More

Bronchial asthma is characterized by an eosinophilic inflammatory process in the airways, and manifests itself functionally by bronchial hyperresponsiveness and variable airflow obstruction. In the past this inflammatory process was presumed to be predominantly present in the large and intermediate airways. This is not surprising since functional abnormalities in the small airways (or so-called silent zone) are mu Read More

Amorphous materials have always been an essential part of pharmaceutical research They are important because of their characteristic solubility characteristics, common occurrence, and physicochemical instability relative to corresponding crystals. Some pharmaceutical agents have a tendency to exist as amorphous solids, while others require prevention of their crystallization to remain in the amorphous state in order Read More

Renal biopsy was broadly used for research in some institutions of the former Soviet Union: it was performed in patients with amyloidosis, renovascular hypertension (both kidneys), pyelonephritis and chronic alcoholism. When renal biopsy was performed in accordance with clinical indications, a part of the tissue cylinder was sometimes consumed for scientific purposes. Renal biopsy was performed in clinically inacti Read More

A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a multifunctional transducing organ that regulates cardiovascular homeostasis. Disruption of endothelial integrity, as a result of either angioplasty or stent deployment, may produce a late in-stent restenosis and limit the beneficial outcome of reconstructive vascular surgery. Restoration of endothelial lining requires spreading, migration and prolif Read More

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease arising from monoclonal proliferation of B lymphocytes. In the absence of poor risk features, CLL is characterized by an indolent clinical course but in 2012 it is still considered an incurable malignancy. Treatment of CLL is highly individualized and the majority of patients do not require treatment at the time of diagnosis. Therapy is, however, indicated for patients Read More