Current Drug Therapy - Volume 7, Issue 3, 2012

Psychosis in Parkinson Disease (PDP) is a common clinical problem and presents a pharmacological therapeutic conundrum. Many patients with PDP require anti-parkinsonian drugs for motor control, but the use of these medications has been associated with worsening of the psychotic symptoms. Differences from other psychotic disorders include the association with the use of anti-parkinsonian drugs, and the common Read More

Introduction: Many patients with Parkinson's disease (PD) require hospitalization for medical or surgical problems other than motor features of PD, and are often admitted to non-neurological wards. Objectives: To assess the prevalence of inappropriate antidopaminergic drug use (prescription and administration) among PD inpatients. Other objectives were to study an association between chronic antidopaminergic prescription Read More

With the present scenario of development of newer drug delivery systems, correspondingly various routes are also being explored for systemic or local drug delivery to the patients. In the same context, nasal drug delivery is serving as a very effective route for the delivery of therapeutically active compounds. In such drug delivery system, drugs having lower absorption rate can be administered with the use of absorption enh Read More

Metallo β lactamase (MTLs) are a subtype of enzymes causing resistance to carbapenems which are reported in many countries all over the world. This is of great concern as carbapenems are the most potent agents in treating multidrug resistance Enterobacteriaceae. The aim of this study was detection of metallo β lactamase producing Enterobacteriaceae from patients and associated risk factors with resistance in Sanandaj ho Read More

Transdermal delivery offers opportunities for inventive, challenging and valuable research with patient benefits. However, the prominent challenge in designing transdermal drug delivery systems is to overcome the natural transport barrier of the skin, the stratum corneum. Several physical and chemical enhancement techniques have been investigated in the last decade to breach the skin barrier and assist the transport of macr Read More

Rheumatoid arthritis is a chronic auto-immune disease that is characterized by both localized and systemic inflammation of internal organs and joints. Elevated plasma concentrations of pro-inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1b (IL-1b), tumor necrosis factor- α (TNF-α), and acute phase proteins, are responsible for both localized and systemic inflammation. Rheumatoid arthritis is a disease which Read More

The treatment of depression in older people needs an integrated approach with pharmacological and psychosocial approaches working together. Within secondary mental health services there are patients with severe depression who are often at a significant risk. There is evidence to suggest the older antidepressants are over prescribed to the elderly in primary care and there are gaps in the assessment information recorded Read More

Liposomal hydrogel as a wound dressing provides a barrier that effectively prevents the contamination of the wound and further progression of infection to deeper tissues. The drug encapsulated within the liposomes increases the drug concentration locally and decreases systemic drug concentration and hydrogels combine the features of moist wound healing with good fluid absorbance. And act as a barrier against bact Read More