Skip to content
2000
Volume 23, Issue 5
  • ISSN: 1389-4501
  • E-ISSN: 1873-5592

Abstract

The quinolinic ring, present in several molecules, possesses a great diversity of biological activities. Therefore, this ring is in the structural composition of several candidates of drugs in preclinical and clinical studies; thus, it is necessary to compile these results to facilitate the design of new drugs. For this reason, some of the activities of compounds are selected to examine in this review, such as antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic, and antiviral activities. All publications of scientific articles chosen are dated between 2000 and 2020. In addition to presenting the structures of some natural and synthetic compounds with their activities, we have listed the clinical studies of phases III and IV on antimalarial drugs containing the quinoline nucleus and phase III clinical studies on hydroxychloroquine and chloroquine to assess their possible role in COVID-19. Finally, we have reviewed some of the mechanisms of action, as well as the side effects of some of the quinolinic derivatives.

Loading

Article metrics loading...

/content/journals/cdt/10.2174/1389450122666210415100151
2022-04-01
2025-05-28
Loading full text...

Full text loading...

/content/journals/cdt/10.2174/1389450122666210415100151
Loading

  • Article Type:
    Review Article
Keyword(s): antimalarials; chloroquine; Clinical trials; COVID-19; pharmacology; quinolinic ring
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test