Full text loading...
- ISSN: 1389-4501
- E-ISSN: 1873-5592
-
Emerging Concepts for the Treatment of Hematological Malignancies with Therapeutic Monoclonal Antibodies
- Source: Current Drug Targets, Volume 11, Issue 7, Jul 2010, p. 790 - 800
-
- 01 Jul 2010
Abstract
The development of therapeutic monoclonal antibodies (mAbs) has revolutionized the treatment of cancer along the last ten years. The best examples of their therapeutic efficacies have been obtained with rituximab for the treatment of CD20+ B-cell Non-Hodgkin Lymphoma (B-NHL), and several others antibodies with optimized bioactivities are now being developed for the treatment of various malignant hemopathies. We review here the main drugs developed in this field, and present some emerging concepts able to improve the bioactivities of the next generation of therapeutic mAbs.
© Bentham Science Publishers