Current Bioactive Compounds - Volume 2, Issue 1, 2006

Conventional drug development, which likely to be remain a dominant strategy in the near future, is based on the discovery of potent molecular entities. Scientific literature is full of the reports of discovery or development of interesting molecular exciting against different therapeutic targets. However, only a handful of these exciting discoveries are seriously followed mainly due to lack of access to most readily available and u Read More

Several families of novel synthetic ion channels have now been developed. They exhibit many, but not all, of the properties of protein ion channels. Some are peptides, but none is naturally occurring. Their ability to insert in membranes and disrupt ion homeostasis confers cellular toxicity upon them. Because these compounds are both abiotic and cytotoxic to a range of microbes, they have been investigated as antibiotics.

In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.

Eugenol (4-allyl-2-methoxyphenol) is a fragrant compound that is commonly contained in various sorts of plants, especially in spices and medicinal herbs. Eugenol has been used for dental analgesic, which also has anticonvulsive and anti-microbial activities. Besides, anti-inflammatory and antioxidative activities of eugenol are known. A body of evidence suggests that eugenol can be used as a drug for treatment of Alzheim Read More

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