Current Bioactive Compounds - Volume 2, Issue 3, 2006

Since AIDS was first recognized in the early eighties, more than 25 million people have died and tens of millions of people have been infected with HIV. Presently more than 40 million men, women and children are living with HIV. In the most affected countries, AIDS dramatically diminishes life expectancy and economic potential, by killing people in the prime of their lives, and undermines the future generations by creating milli Read More

The effects of the aqueous extract of Sesamum radiatum Schum & Tonn (ESera) were studied on the cardiovascular system of mammalians. ESera administered intravenously (6 x 10-4 g/kg b.w. - 5.7 x 10-2 g/kg b.w.), caused a decrease in the arterial blood arterial pressure (hypotension) in a dose-dependent manner (ED50 =0 1.3 x 10-2 g/kg b.w.). These effects induced by ESera were reversed in the presence of atropine at a Read More

Bioactive compounds capable of interacting with tubulins and microtubules represent powerful weapons in cancer chemotherapy. Most of these compounds, including the well-established chemotherapeutic agents colchicine (1), podophyllotoxin (3), vinblastine (4) and vincristine (5) that interfere with the formation and growth of microtubules, or Taxol (11) and the epothilones (12-13), which promote tubulin polymerizatio Read More

Twenty-five years ago, alfacalcidol arrived on the scene as a prodrug of the active form of vitamin D3, calcitriol [1,25(OH)2D3] to remedy vitamin D3 deficiency. With the concurrent reported discovery of the differentiation-inducing effect of active vitamin D3, its diverse physiological effects have become appreciated and the research aiming to accentuate selected physiological effects by analog synthesis has made a fresh d Read More

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available

Full text available