Current Bioactive Compounds - Volume 2, Issue 4, 2006

Proliferation and differentiation of stem cells are regulated by plural cytokines. One of those cytokines, thrombopoietin (TPO), a 332 amino acid protein, stimulates proliferation of hematopoietic stem cells, and differentiates them into megakaryocytic progenitor cells which in turn transform into megakaryocytes, direct precursors of platelets. Dysfunction in platelet production - thrombocytopenia, which can contribute to furth Read More

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generally thought to be important mediators of various pathological conditions. Since fluorescent probes are promising tools for clarifying the functions of biomolecules in biological systems as demonstrated by the case of Ca2+ fluorescent probes, interest in the use of fluorescent probes for sensing ROS/RNS is increasing. Although fluorescent prob Read More

Human interferons (IFNs) form a family of cytokines produced by a large number of cells. On the basis of their physicochemical and biological properties, the IFN family can be subdivided into two subtypes: the Type I IFNs (α,β,ω) and the Type II IFN represented by IFN-γ. IFN binding to specific cell surface receptors activates the Jaks kinases which phosphorylate Stats leading to their dimerization, translocation to the nuc Read More

In this review we will briefly survey the oxidation chemistry of the catechol estrogens (2-hydroxy- and 4- hydroxyestradiol, 2-OH-E and 4-OH-E) as a result of the research carried out in the authors' laboratory and other centers during the past decade. The central focus of the paper will be on the main pathways of oxidative modification and their possible relevance to the mechanisms of estrogen-related carcinogenesis. The chemi Read More

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