Current Alzheimer Research - Volume 21, Issue 7, 2024

Alzheimer’s Disease (AD) is characterized by synapse loss and neurodegeneration, which leads to cognitive and psychiatric symptoms. Researchers worldwide have been studying therapeutic approaches aiming to induce plasticity and neuroprotection once AD has no cure and the existing treatments are limited. Environmental Enrichment (EE) is a change in housing conditions that promotes increased cognitive stimulus. St Read More

IntroductionThe COVID-19 pandemic has had multifaceted and enduring impacts on people with dementia and their caregivers; however, our understanding of the long-term outcomes remains limited. We aimed to explore the long-term effects of the COVID-19 pandemic on cognitive symptoms and vaccination rates in people living with dementia.MethodsThis study was conducted as a part of a longitudinal study desig Read More

IntroductionAlzheimer's Disease (AD) is the most common neurodegenerative disease, and timely and effective diagnosis is essential for the prevention and treatment of AD. Peripheral blood is readily available, inexpensive, and non-invasive, making it an ideal substrate for screening diagnostic biomarkers.MethodsThe Notch signaling pathway is closely related to AD, so genes related to the Notch signaling pathway ma Read More

BackgroundAlzheimer's Disease (AD) is characterized by a progressive neurodegenerative process leading to cognitive decline and functional impairment. Endocrine factors, particularly sex hormones and their binding proteins, play a critical role in AD pathophysiology. Understanding the relationship between these factors and AD is essential for developing targeted interventions.ObjectiveTo investigate the potential links b Read More

Introduction/ObjectiveAlzheimer's Disease and Related Dementias (AD/ADRD) present significant caregiving challenges, with increasing burdens on informal caregivers. This study examines the potential of AI-driven Large Language Models (LLMs) in developing digital caregiving strategies for AD/ADRD. The objectives include analyzing existing caregiving education materials (CEMs) and mobile application descriptions (MADs) an Read More

BackgroundThe association between physical activity (PA) and cognitive function remains controversial, and the impact of gender on this association remains underexplored. Therefore, this study aimed to investigate the association between PA and cognitive function and to explore whether this association was modified by gender among older adults.MethodsIn 2016, a cluster sampling method was used to select co Read More