Current Alzheimer Research - Volume 21, Issue 5, 2024

Alzheimer’s disease (AD) is a devastating neurological disorder that affects synaptic transmission between neurons. Several theories and concepts have been postulated to explain its etiology and pathogenesis. The disease has no cure, and the drugs available to manage AD symptoms provide only modest benefits. It originates in the brain’s entorhinal cortex (EC), with tau pathology that poses overt symptoms for decades and t Read More

BackgroundIn an ageing population, dementia has become an imminent healthcare emergency. Capgras syndrome, the most common delusion of misidentification (DMS), is frequently found alongside dementia. Previous research showed that Capgras syndrome has significant negative effects on people living with dementia and their carers due to its complex presentation and impact on their lives. This qualitative systematic revi Read More

IntroductionWhen Ant Colony Optimization algorithm (ACO) is adept at identifying the shortest path, the temporary solution is uncertain during the iterative process. All temporary solutions form a solution set.MethodsWhere each solution is random. That is, the solution set has entropy. When the solution tends to be stable, the entropy also converges to a fixed value. Therefore, it was proposed in this paper that apply entropy as a Read More

BackgroundAmnestic Mild Cognitive Impairment (aMCI) is a prodromal phase of Alzheimer's disease. Although recent studies have focused on cortical thickness as a key indicator, cortical complexity has not been exhaustively investigated.ObjectivesTo investigate the altered patterns of cortical features in aMCI patients and their correlation with memory function for early identification.Methods25 aMCI patients and 54 no Read More

BackgroundDisease progression in Alzheimer’s Dementia (AD) is typically characterized by accelerated cognitive and functional decline, where heterogeneous trajectories can impact the observed treatment response.MethodsWe hypothesized that unobserved heterogeneity could obscure treatment benefits in AD. The effect of unobserved heterogeneity was empirically quantified within the Alzheimer’s Management By Alb Read More