Current Analytical Chemistry - Volume 20, Issue 5, 2024

In diagnostic technologies, search for quick, accurate, and cost-efficient ways to confirm diseases has prompted the investigation of alternative methodologies to classic PCR-based tests. This article delves into the growing field of nanoparticle-based immunoassays, offering a comprehensive evaluation of their potential as viable alternatives to PCR for disease diagnostics. We discuss the basic principles of nanoparticle-based i Read More

For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of small polar molecules. From the efforts to solve the problem of insufficient retention of these molecules, during the last decades, a mode of liquid chromatography named Hydrophilic Interaction Liquid Chromatography (HILIC) has Read More

Background: Diabetes mellitus is a significant medical condition with rising incidence and fatality rates. According to WHO, around 422 million individuals globally have diabetes, the majority of whom live in low and middle-income economies. Diabetes is entirely responsible for 1.5 million fatalities yearly. Researchers are concentrating on plant derivatives due to the higher toxicity of conventional allopathic medicines. Antid Read More

Introduction: Crude oil is a complex blend of various hydrocarbon families, with compositions that vary depending on the source well and exploitation duration. To categorize its constituents, SARA analysis divides them into saturated, aromatic, resins, and asphaltenes. Heavy asphaltene- rich crude oils can present challenges like viscosity and pipeline blockages, which are often addressed with viscosity-reducin Read More

Background: Both Salvianolate Injection and warfarin are widely prescribed in patients with cardiovascular diseases, but the interaction between them is unknown and needs to be investigated. Objective: This research aims to study the effects and mechanism of Salvianolate Injection on the pharmacodynamics and pharmacokinetics of warfarin in rats. Methods: Male Wistar rats were intraperitoneally injected Salvianolate Inje Read More

Background: A safe and long-term isolation of radionuclides is crucial for efficient waste management in the nuclear fuel cycle. Clay minerals of geological origin are considered candidate barrier materials for the sequestration of nuclear waste for geological disposal applications. Objective: The present study encompasses a systematic characterization of weathered basalt rock and the influence of its constituent clay mineral Read More