Current Analytical Chemistry - Volume 19, Issue 5, 2023

The recent development of microfluidics and lab-on-a-chip technology has substantially raised interest in analytical chemistry. Since, they have demonstrated to be extraordinarily adept at precise fluid control, cell manipulation, and signal output, microfluidic chips are a useful tool for quick and in-depth single-cell investigation. This technique is cost-effective, less time-consuming, automatic, high mobility, and fast separation Read More

In recent years, size exclusion chromatography (SEC) has gained valuable and impactable recognition among various chromatographic techniques. Also addressed as other names, viz. gel permeation chromatography, steric-exclusion chromatography, etc., SEC is typically taken into consideration for the fractionation and molecular weight determination of biomolecules and large macromolecules (proteins and polym Read More

Introduction: The current investigation's objective was to develop an HPLC method along with a validated stability-indicating method and analyzing the behavior of levocetirizine degradation under various ICH-suggested stress conditions using LC-UV and LC-MS with a triple quadrupole mass analyzer. Methods: Levocetirizine was exposed to various stressors while performing degradation studies. Using LC-UV and LC-MS metho Read More

Introduction: The objective of this study is to provide a rapid, sensitive, consistent, and costeffective method for quantifying isradipine using ultra-fast liquid chromatography. Methods: Quality by Design principles will form the basis of this approach, grounded on response surface analysis. Shimadzu liquid chromatographic system equipped with a photodiode array detector and LC solution software was used to conduct the Read More

Introduction: The present work fits in the context of verifying the safety of some food contact materials (FCMs) declared sustainable, checking for the presence of different classes of contaminants and their possible migration. Background: Alternative packaging materials have started to step in the market in substitution to plastic for several years. Most of them come from natural, biological sources to meet biodegradability and Read More

Introduction: UPLC coupled with a high-resolution mass analyzer i.e, Q-TOF analyzer with electrospray ionization (ESI) source using collision-induced dissociation (CID) method was applied to study the characteristic product ions of azilsartan protonated ion. Method: The experimental results of high-resolution mass spectra explained the elemental compositions of product ions accurately and reasonable fragmentation pathways Read More