Current Analytical Chemistry - Volume 19, Issue 7, 2023

Food safety has received increasing attention, and pesticide contamination is one of the primary issues. Many toxicological endpoints have been established to evaluate the hazards of pesticides. However, the sensitivity of toxic endpoints is dominated by analytical methods. The risks of pesticides may be underestimated when using insensitive analytical methods to establish the toxicological endpoints. Therefore, it is nec Read More

Nilotinib hydrochloride is a tyrosine kinase inhibitor licensed to treat chronic myelogenous leukemia in patients with the Philadelphia Chromosome (Ph+). Researchers at Novartis Pharmaceuticals discovered novel inhibitors that are effective against imatinib-resistant BCR-ABL mutations. As a consequence, Nilotinib was discovered. Several analytical approaches were employed to address the quantitative as well as qualitative a Read More

Background: Sufentanil, an opioid analgesic, is used as an induction agent for general anesthesia during surgery. Sufentanil is more active than other anesthetics and has a narrow therapeutic range. Therefore, a precise dosage regimen is necessary when administering sufentanil.Objective: This study aimed to develop a bioanalytical method for the determination of sufentanil within the sensitive concentration range more th Read More

Background: Initially synthesized as an antidepressant and potentially rapid onset of action, flibanserin (FLB) was approved by the Food and Drug Administration (FDA) in August 2015 with a warning to dispense the drug through a dedicated risk management program, despite the removal of HSDD from the DSM-5TM. The drug is the first noteworthy FDA-approved drug for treating premenopausal women with acquired, gener Read More

Background: Green synthesis of nanomaterials is promising as a biological source for treating different diseases without side effects.Methods: In the present study, marine Streptomyces sp. was used to biosynthesize silver nanoparticles, which were then characterized and evaluated for various therapeutic activities and A 549 breast cancer cell line for cytotoxic evaluation.Results: The Surface Plasmon Resonance exhibited a pea Read More

Background: Nigella sativa is a traditional plant with several ethno-medicinal activities. There have been several health advantages associated with Nigella sativa (Ns) L. oil, which has a high concentration of bioactive compounds.Method: This research aimed to examine the fatty acid methyl ester profiles, microbiological profiles, and aflatoxin profiles of cold-pressed Ns oils acquired from Turkish herbalists. For this, the fatty a Read More