Current Analytical Chemistry - Volume 19, Issue 9, 2023

Cancer remains a formidable global health challenge, underscoring the critical need for early and accurate diagnostic tools. In recent years, nanotechnology has emerged as a promising frontier in cancer detection, offering innovative approaches to enhance sensitivity, specificity, and convenience in diagnostics. This comprehensive review delves into the intersection of nanotechnology and sputum-based assays for can Read More

Background: The infection caused by the dengue fever virus is a severe threat to public health on a global scale; nevertheless, there is currently no effective medical treatment or vaccine available to prevent or treat the condition. Objective: To better understand the physicochemical regularities of these proteins, it is necessary to carry out a computational multiparametric study of the amino acid sequences of envelope proteins e Read More

Background: Silymarin (SM) is a mixture of seven flavonolignans (FL) and one flavonoid extracted from the seeds of the milk thistle plant. The major FLs include silibinin, silychristin, silydianin, and isosilibinin. Silibinin, a mixture of two diastereomers, i.e., silybin A and silybin B, has been found to be the most active biomarker molecule in the extract of SM. Some studies have also demonstrated the usefulness of other biomarkers. Ho Read More

Background: Saxitoxin (STX) stands as one of the most potent marine biotoxins, exhibiting high lethality. Despite its severity, current treatments remain ineffective, and existing detection techniques are limited due to ethical concerns and technical constraints. Methods: Herein, an innovative approach was constructed for STX detection, utilizing mesoporous silica nanoparticles (MSN) as a foundation. This innovative, easy, and Read More

Background: In borax buffer, ephedrine (EPH) and pseudoephedrine (PSE) can be well separated (Rs>10) in capillary electrophoresis (CE) without adding any other compounds, but the specific mechanism remains unclear. Methods: Titration analysis, nuclear magnetic resonance analysis, mass spectrum analysis and molecular modeling were used to investigate the separation mechanism. Results: Tetrahydroxy borate (a hydroly Read More