Current Analytical Chemistry - Volume 16, Issue 8, 2020

Background: Selenium’s popularity in a wide variety of products and industries means that it has, unfortunately, become a common environmental pollutant, particularly from sources such as industrial wastewater discharge and agricultural runoff. Objective: Quantification of the selenium (IV) ion content of natural water sources via atomic fluorescence spectrophotometry (AFS) was performed using hollow ZnO microflowers a Read More

Background: A lack of regulation about the chemical composition of essential oils and the growing popularity of these oils among consumers presents an urgent need for the accurate characterization of various oil types from a variety of manufacturers. The aim of this paper was to characterize the composition of essential oils bought from a popular retail location, with the goal of understanding the chemical compos Read More

Background and Objectives: Contamination of aquatic sediments by trace metals is one of the global problems. This is because trace metals in sediments are persistent and nonbiodegradable. They may pose danger to flora and fauna since they can be released into freshwater systems. This study aimed at the development of microwave-assisted extraction using diluted hydrogen peroxide and nitric acid for extraction of trace Read More

Background: Losartan, one of the most frequently used drugs in Heart Failure (HF) treatment, could be modified for its bioavailability (BA) by generic formulations and other factors. Hence, the importance of therapeutic drug monitoring. Objective: Development and validation of a simplified analytical method using HPLC for simultaneous quantification of losartan and E-3174 in human plasma samples. The method Read More

Background: Simple, sensitive, and economic colorimetric device based on a smartphone digital image coupled with Color Grab™ application was developed for DCH drug determination. The method is based on the diazotization reaction of benzocaine with DCH drug to get an orange azo dye. Methods: Variable parameters such as volumes of reagents, the internal walls and ambient light have been analyzed and optimized. Fro Read More

Background: Hypertension is a major risk for morbidity and mortality, while hypertension is associated with cardiovascular disease and organ damage. Recent research efforts have focused on the development of highly selective angiotensin receptor blockers. In which losartan (LOS) is considered as a new generation of an effective oral drug product against arterial hypertension. Therefore, the determination of drugs in Read More

Background: Lamotrigine (LTG), topiramate (TPM), and oxcarbazepine (OXC) are commonly used antiepileptic drugs. The bioactivity and toxicity of these drugs were related to their blood concentrations which varied greatly among individuals and required to be monitored for dose adjustment. However, the commercial method for monitoring of these drugs is not available in China. Methods: A UHPLC-MS/MS method for simultan Read More

Background: Cadmium (Cd2+) is considered to be one of the most important hazardous heavy metals due to its toxicity for living organisms at low concentration levels. Therefore, the estimation of trace Cd2+ in different types of various samples is a very important objective for chemists using effective methods. In the present work, a novel, green, easy and fast ultrasoundassisted ionic liquid-dispersive liquid phase microextracti Read More

Background: Analysis of drug concentrations in biological fluids is required in clinical sciences for various purposes. Among other biological samples, exhaled breath condensate (EBC) is a potential sample for follow up of drug concentrations. Methods: A dispersive liquid-liquid microextraction (DLLME) procedure followed by a validated liquid chromatography method was employed for the determination of budesonide (BDS) in Read More

Background: The determination of mancozeb, a fungicide extensively used in agriculture, is a challenge, due to the nature of the compound, a manganese and zinc complex of ethylenebis dithiocarbamate and because of the general instability of the dithiocarbamates. Methods: Mancozeb was analyzed in a GC-EI-MS system after derivatization by CE-UV with detection at 280 nm and in LC-ESI-MS-MS in MRM mode. Results: Read More

Background: Catalase is a vital antioxidant enzyme that dismutates H2O2 into water and molecular oxygen. Many protocols have been developed to measure catalase enzyme activity. Spectrophotometric methods are the most common assays that used to assess catalase enzyme activity. Methods: Because the rate-limiting step during catalase enzyme activity depends upon the dissociation of hydrogen peroxide, the devel Read More

Background: Paracetamol is a common antipyretic and analgesic drug, but its excessive intake can accumulate toxic metabolites and cause kidney and liver damage, so it is critical to determine the content of paracetamol for clinical diagnosis and dose use. Methods: Au-reduced graphene oxide (Au-rGO) nanocomposite decorated with poly(L-cysteine) on carbon paste electrode was fabricated for the determination of paracetam Read More

Background: Multivariate analysis is a chemometric tool that has been little explored to determine physiological status under heavy metal stress. Nevertheless, PCA has an unexplored potential to determine the plant physiologic status and its modification under stress factors like heavy metals. Objectives: This work aims to assess the physiological and biochemical effects and responses of wheat plants under the different exposit Read More

Background: The elemental composition of maize grains depends on the soil, land and environment characteristics where the crop grows. These effects are important to evaluate the availability of nutrients with complex dynamics, such as the concentration of macro and micronutrients in soils, which can vary according to different topographies. There is available scarce information about the influence of topographic chara Read More

Background: The poly(ADP-ribose) polymerases (PARP) is a nuclear enzyme superfamily present in eukaryotes. Methods: In the present report, some efficient linear and non-linear methods including multiple linear regression (MLR), support vector machine (SVM) and artificial neural networks (ANN) were successfully used to develop and establish quantitative structure-activity relationship (QSAR) models capable of pr Read More

Background: Axitinib (AXT) is a member of the new generation of the kinase inhibitor indicated for the treatment of advanced renal cell carcinoma. Its therapeutic benefits depend on assuring the good-quality of its dosage forms in terms of content and stability of the pharmaceutically active ingredient. Objective: This study was devoted to the development of a simple, sensitive and accurate stabilityindicating high-performanc Read More