Current Analytical Chemistry - Volume 16, Issue 7, 2020

Background: Analytical scientists have constantly been in search for more efficient and economical methods for drug simulation studies. Owing to great progress in this field, there are various techniques available nowadays that mimic drug metabolism in the hepatic microenvironment. The conventional in vitro and in vivo studies pose inherent methodological drawbacks due to which alternative analytical approaches are dev Read More

Background: The properties of materials depend on the way of construction and the arrangement of atoms and molecules. Therefore, it is very important to know synthesis methods for the preparation of novel materials as per their desired structure. The low-temperature synthesis methods, such as polymeric citrate precursor and sonochemical methods are efficient enough to control the preparation of novel nanoparticles wi Read More

Background: Immunoglobulin A (IgA) accounts for 15% of total protein production per day and plays a crucial role in the first-line immune defence. Recently, IgA has been established as a vital clinical biomarker for nephropathy, allergic asthma, celiac disease (CD), pneumonia, and asthma as well as some neurological disorders. In this work, we have studied several carbon nanomaterials (CNMs) having different dimensions (D): Read More

Background: The increasing demand of effective pharmaceutical products directed to fight against malaria lead to the combination of at least two antimalarial drugs. This combination aims to minimize the Plasmodium falciparum resistance which is found when the most frequently used drugs are taken individually. Within this context, proguanil hydrochloride and chloroquine phosphate which have independent modes of action Read More

Background: An efficient, selective and durable electrocatalytic carbon dioxide (CO2) reduction system is a prerequisite to tackle energy and pollution-related issues. In this context, both organic and inorganic materials have gained a significant interest worldwide. Objective: In the present work, the electrocatalytic reduction activity of an iron-sulphur (Fe-S) cluster, [Fe4S4(SPh)4]2– for CO2 → carbon monoxide (CO) conversi Read More

Background: A rapid and simple analytical method for the screening and quantification of multi-residues was established by a quick, easy, cheap, effective, rugged and safe (QuEChERS) approach coupled to ultra-performance liquid chromatography and electrospray ionization quadrupole orbitrap high-resolution mass spectrometry (UPLC-Q-Orbitrap HRMS). A total number of 59 veterinary drugs were investigated, which be Read More

Background: In this work, Cr (VI) adsorption on nano-ZrO2TiO2 impregnated orange wood sawdust (ZrTi/OWS) and nano-ZrO2TiO2 impregnated peach stone shell (ZrTi/PSS) was investigated by applying different adsorption parameters such as Cr (VI) concentrations, contact time, adsorbent dose, and pH for all adsorbents. Methods: The adsorbents were characterized by SEM and FT-IR. The equilibrium status was achieved aft Read More

Background: The official compendium of the quantification of ginkgo flavonoids from Ginkgo biloba extract has been proposed using HPLC. The drawbacks of this technique appear to be due to the restricted efficiency in terms of the recovery results and suitability of the system for the quantification of these compounds. This study investigated the potential advantages and limitations of the development of efficient extr Read More

Background: L-Ascorbic acid (AA) is a kind of water soluble vitamin, which is mainly present in fruits, vegetables and biological fluids. As a low cost antioxidant and effective scavenger of free radicals, AA may help to prevent diseases such as cancer and Parkinson’s disease. Owing to its role in the biological metabolism, AA has also been utilized for the therapy of mental illness, common cold and for improving the immunity. The Read More

Background: Kuding tea, a Traditional Chinese drink, has a history of thousands of years in China. Triterpenoid saponins in Kuding tea are regarded as one of the major functional ingredients. Objective: The aim of this paper was to establish separation progress for the isolation and purification of five triterpenoid saponins (kudinoside A, C, D, F, G) from Kuding tea. Methods: Nine types of resins, including seven macroporous resins Read More

Background: A new method has been developed for the determination of food dye tartrazine in soft drinks. Tartrazine is determined by hyphenated technique Ultra Performance Liquid Chromatography coupled with Mass spectrometry. The solid-phase extraction was used for the extraction of tartrazine. Methods: For the LC-MS analysis of tartrazine acetonitrile, water (80:20) was used as a mobile phase whereas, the C-18 colu Read More

Background: Zeolitic imidazolate frameworks with three metals Zn, Co and Ag (ZIF-3M) and ZIF-67 were synthesized at room temperature and characterized with different techniques such as FESEM, BET, EDX and XRD. Then, the synthesized nanoparticles were successfully applied for the removal of levofloxacin from aqueous solutions. Methods: To optimize the significant factors (i.e., pH, adsorbent dose and contact time), Read More

Background: MBT, a rubber accelerator, was popularly used in rubber manufacturing. However, the experts from the International Agency for Research on Cancer suggested that MBT was listed in Group 2A carcinogenic material. Methods: Therefore, we developed a quantification method based on LC-QqQ-MS/MS, using isotopic iodoacetamide and 13C2, D2-iodoacetamide to react with the thiol group on MBT to generate th Read More