Current Analytical Chemistry - Volume 16, Issue 4, 2020

Background: Nano level chiral separation is necessary and demanding in the development of the drug, genomic, proteomic, and other chemical and the environmental sciences. Few drugs exist in human body cells for some days at nano level concentrations, that are out of the jurisdiction of the detection by standard separation techniques. Likewise, the separation and identification of xenobiotics and other environmental cont Read More

Background: Today, “drugs of abuse” pose serious social problems such as many crimes, medical treatment costs, and economic repercussions. Several worldwide clinical laboratories use analytical separation methods to analyze their patient samples for drugs and poisons. In this way, they provide qualitative and quantitative data on the substances in various biological matrices (e.g., urine, plasma or serum, saliva, and breat Read More

Background: Cadmium (Cd2+) and lead (Pb2+) have acute and chronic effects on humans and other living organisms. In the present work, new, green and accurate dispersive micro solid-phase extraction (DμSPE) method for the separation and preconcentration of trace amounts of cadmium (Cd2+) and lead (Pb2+) ions in various food, water and tobacco samples collected from Saudi Arabia prior to its Flame Atomic Absorptio Read More

Introduction: In this study, solar exfoliated graphite oxide modified glassy carbon electrode was used for the anodic oxidation of epinephrine in a phosphate buffer medium at pH7. The modified electrode showed fast response and sensitivity towards Epinephrine Molecule (EP). The electrode was characterized electrochemically through Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV). Area of the electrode e Read More

Background: The red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) is one of the world’s most serious stored grain insect pests. A method of early and rapid identification of red flour beetle in stored products is urgently required to improve control options. Specific chemical signals identified as Volatile Organic Compounds (VOCs) that are released by the beetle can serve as biomarkers. Methods: Th Read More

Background: As a broad-spectrum antibiotic of the sulfonamide family, Sulfadimethoxine (SDM) has been widely utilized for therapeutic and growth-promoting purposes in animals. However, the use of SDM can cause residual problems. Even a low concentration of SDM in the aquatic system can exert toxic effects on target organisms and green algae. Therefore, the quantitation of SDM residues has become an important task. Me Read More

Background: Nowadays, polymeric composites modified with carbonaceous nanomaterials have been popular due to their greater application potentials in many application fields. However, the structural consistency of the composite prepared by electropolymerization suffers from agglomeration of Carbon Nanotubes (CNTs) probably due to their poor dispersion in the coating solution. Present study describes a new Read More

Background: Simeprevir is one of the recently discovered drugs for treating hepatitis C which is one of the major diseases across the globe. Objective: The present study involves the development of a new and unique High-Performance Liquid Chromatography (HPLC) method using fluorescence detection for the determination of simeprevir (SIM) in human plasma. Methods: Two methods of extractions were tested, p Read More

Background: Parabens are synthetic esters used extensively as preservatives and/or bactericides in personal care personal products. Objective: Development and validation of a novel robust chemometric assisted analytical technique with superior analytical performances for the determination of ethylparaben, methylparaben and propylparaben, using simulated wastewater matrix. Methods: An automated Solid P Read More

Background: Quetiapine Fumarate (QTF) is an atypical antipsychotic drug used to treat mental disorders as depression and schizophrenia. The analysis of the dug in the presence of its precursors, degradants and impurities without interference represents a challenge for the analysts. The regulatory requirements recommended by ICH stated that the impurities above or equal to 0.1% must be identified, characterized and d Read More

Background: A simple, eco-friendly and low-cost Infrared (IR) method was developed and validated for the analysis of Cefepime Hydrochloride (CEF) in injectable formulation. Different from some other methods, which employ organic solvents in the analyses, this technique does not use these types of solvents, removing large impacts on the environment and risks to operators. Objective: This study aimed at developing a Read More

Background: Cyclic voltammetry is widely employed in electroanalytical studies because it provides fast information about the redox potentials of the electroactive species and the influence of the medium on the redox processes. Azole compounds have been found to be effective corrosion inhibitors for copper in chloride-containing solutions. The aim of this work was to investigate in detail the influence of the addition of vari Read More

Background: Sarin is a nerve agent which is lethal to people due to its high toxicity. According to its extreme toxicity, sarin, relatively lack of color, highly toxic, miscible in water, poses viable threats to potable water sources. Therefore, there is an urgent need for portable, rapid and yet reliable methods to monitor for adulteration of potable water sources by sarin on spot. Methods: A stock solution of 30 mg/L sarin was prepared Read More

Background: Owing to the strong oxidizing and reducing properties of hydrogen peroxide (H2O2), it has been widely used in many fields. In particular, H2O2 is widely used in the aseptic packaging of drinks and milk. The residue of H2O2 in food is harmful to human health. Therefore, the quantitative detection of H2O2 is of great practical significance. Methods: The Ag-Au/RGO/TiO2 nanocomposites were facilely synthesize Read More

Background: Formaldehyde has been recognized as the important liquid environmental pollutant which can cause health risk. Great effort has been devoted to detecting formaldehyde in liquid environment. It is of important significance to develop a sensitive method for measuring formaldehyde from the environmental and health viewpoints. Methods: Polyaniline/graphene nanocomposites have been prepared by a simple in-situ p Read More