Recent Advances in Anti-Infective Drug Discovery - Current Issue

Medicinal plants are an integral part of the medical system in many countries around the world. Natural products have been used as important biological sources for drug discovery over the past half-century. Alkaloids are a group of natural compounds that contain a basic nitrogen atom. Oxoglaucine is a phytochemical of the oxoaporphines class phytochemical isolated from Aquilegia ecalcarata Maxim, Corydalis yanhusu Read More

Multidrug-resistant tuberculosis (MDR-TB) poses a persistent challenge to global health, necessitating continuous efforts to enhance treatment efficacy. Bedaquiline, a cornerstone in MDR-TB management, presents biopharmaceutical challenges that impact its therapeutic potential. This review provides a comprehensive analysis of recent innovations in drug delivery strategies designed to optimize Bedaquiline's efficacy a Read More

BackgroundViral infections pose a great burden for humankind and many viruses have no effective treatments. Hepatitis A Virus (HAV) and Coxsackie-B4 (Cox-B4) are common viruses having many drawbacks. Using plant extracts as antiviral agents is a globally applied approach due to its efficacy and minimal adverse effects.ObjectiveThis study aimed to test the antiviral action of the green coffee extract against HAV an Read More

BackgroundThe structural maintenance of chromosomes (SMC) proteins plays a noteworthy role in chromosome dynamics. Several recent studies reported that the condensin core subunits of structural maintenance of chromosomes 2 (SMC2) play important roles in the atypical mitosis of the Plasmodium life cycle and may perform different functions during different proliferative stages. For eukaryotes, the structural maintena Read More

BackgroundInfestation in greenhouse cucumber with the two-spotted spider mite (Tetranychus urticae Koch) commonly causes severe damage to crop quality and quantity and increases crop production costs.ObjectiveThis study was conducted to investigate the efficacy of high-abamectin-producing isolates of S. avermitilis against T. urticae-infested cucumber and to assess their impact on biochemical stress markers in thes Read More