Pharmaceutical Nanotechnology - Online First

Background Different variables have been used for the preparation of elastic nanovesicles. In this work, the ethanol injection method has been used to prepare flunarizine spanlastic nanovesicles and study the potential of these variables on vesicle size, encapsulation efficiency, and vesicle elasticity. Objective The objective of this study was to encapsulate flunarizine dihydrochloride (FHC), a medication with low solubility in w Read More

Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with significant limitations. In TB, long treatment durations, poor compliance, drug resistance, and toxicity of first-line drugs are key challenges. Similarly, pain management faces issues, such as inadeq Read More

Aim This study aimed to develop and evaluate lornoxicam (LXM) and thiocolchicoside (TCS) transferosomal transdermal patches. Background Oral administration of LXM and TCS can lead to gastric irritation, necessitating alternative delivery methods for pain and inflammation relief. Incorporating LXM & TCS into transferosomes within a transdermal patch offers a potential solution. Objective The objective of this study Read More

Even with recent advancements in surgery and multimodal adjuvant therapy, brain cancer treatment is still difficult. The blood-brain barrier and the potentially deadly medications' non-specificity have made pharmacological treatment for brain cancer particularly ineffective. The nanoparticle has surfaced as a viable brain delivery vector that can solve the issues with existing approaches. Furthermore, it is possible to integrate man Read More

Introduction/ Background This study aimed to introduce a gel (NEG) formulation containing betulin-loaded nanoemulsions for topical psoriasis treatment. Materials and Methods The prepared nanoemulsions were optimized for smaller particle size and higher drug content using a response surface methodology that exhibited uniform distribution and high drug loading (21.17±3.55%). Results The gel demonstrated skin-comp Read More

Cancer continues to pose a formidable challenge in global health due to its incidence and increasing resistance to conventional therapies. A key factor driving this resistance is tumor hypoxia, characterized by reduced oxygen levels within cancer cells. This hypoxic environment triggers a variety of adaptive mechanisms, significantly compromising the efficacy of cancer treatments. Notably, hypoxia promotes metastasis an Read More

Alzheimer's disease (AD) is an irreversible brain disorder that led to memory loss and disrupts daily life. Earlier strategies to treat AD such as acetylcholinesterase inhibitor (AChEI) drugs are not showing effectiveness due to the inability to cross the blood-brain barrier. Moreover, traditional AChEI provides limited efficacy in terms of bioavailability and solubility for treating AD treatment. Many of the current drugs such as don Read More

Introduction Metal nanoparticles have received much attention due to their unique physical dynamics, chemical reactivity, and promising biological applications. Green synthesis using natural compounds is an alternative to traditional chemical methods for the synthesis of nanoparticles. Materials and Methods Herein, two secondary metabolites were isolated from different fractions of methanolic extract of Citrullus colocy Read More

Nanotechnology is rapidly transforming various fields, including medicine, environmental conservation, agriculture, and pharmaceuticals. The production of metallic nanoparticles is a key area within this field, known for its innovative applications. However, traditional chemical and physical methods used for nanoparticle synthesis often involve toxic chemicals and are expensive, making them unsuitable for large-scale produ Read More