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Background: Coniothyrium had great potential in controlling Sclerotinia diseases in green houses and field with a high specificity. An important and steadily increasing number of natural products have been isolated from Coniothyrium spp, and the biological activities have not yet been fully elaborated. Objective: To promote the development of Coniothyrium source. Method: To analysis and sum up the literatures concerned. Results: The secondary metabolites of Coniothyrium mainly consisted of polyketides, polyaromatic compounds, and simple aromatic compounds, which have strong biological activity. Conclusion: Coniothyrium spp. as a source of biologically active metabolites is especially signifcant and ensures interest on this subject for years to come.