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Volume 15, Issue 2
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

Mesophotic coral ecosystems (MCEs) are light-dependent ecosystems found from 30 to 150 m in depth that are highly diverse and relatively understudied worldwide.

Methods

One new indole alkaloid, chaetoid A (), one known analog, indigodole B (), and one known -carboline type alkaloid 1-acetyl--carboline (), along with three known cyclic depsipeptides, turnagainolide A (), turnagainolide B (), arthroamide () were isolated from cultures of fungus sp. NBUF152 is associated with a 66 m deep mesophotic zone sponge. Their structures were determined by analysis of spectroscopic data (NMR, HRESIMS, UV, IR, optical rotation, and ECD). The bioassay results showed that compounds - exhibited moderate inhibition against acetylcholinesterase (AchE).

Results

The results showed that these compounds displayed moderate anti-AchE activities with IC values of 25.97, 25.80, 21.07, 23.49, 21.28 and 25.3 mol/L.

Conclusion

This work could lead to additional investigation into the potential of marine organisms in MCEs as a source for discovering natural products with interesting structures and bioactivities.

© 2025 Bentham Science Publishers
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2025-02-01
2024-11-26

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/content/journals/npj/10.2174/0122103155310287240509105635
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Metabolites with Anti-acetylcholinesterase Activities from Marine Mesophotic Zone Halichondria Sponge-associated Fungus Chaetomium sp. NBUF152
Natural Products Journal, The 15, E160524229992 (2025); https://doi.org/10.2174/0122103155310287240509105635
/content/journals/npj/10.2174/0122103155310287240509105635
/content/journals/npj/10.2174/0122103155310287240509105635
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  • Article Type:     Research Article
Keyword(s): acetylcholinesterase; alkaloid; anti-AchE; MCEs; Mesophotic zone; sponge-associated fungi

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