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Volume 15, Issue 1
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Introduction

Healthcare providers globally need plant-derived bioactive compounds for the treatment of ailments. The present systematic review article emphasizes the chemistry and pharmacology parts of various species, family Apiaceae. The species of genus, native to the Indian Himalayan, are beneficial for several therapeutic and edible purposes. Aromatherapy uses essential oils obtained from various species of the genus. The population of various species is declining quickly due to premature destructive harvesting. The traditional medicinal system involves Edgew and other species to treat respiratory, Central Nervous System (CNS) disorders and many more ailments.

Methods

An extensive literature survey on the chemistry and pharmacological aspects of various including , secondary metabolites, mechanism behind various pharmacological activities, and marketed products of plants of Genus was conducted using scientific databases. The search terms species, botanical description, wild , important phytoconstituents and their pharmacological responses, plant parts used, and the molecular mechanism behind observed prominent activities were used for data collection. In total, 92 publications were included from year 1983 to 2023. Articles focusing on other than species and other than the English language were excluded from the study. Also, the papers with no full-text availability were excluded from the present study. Species of the genus have been known for a wide range of biological activities, including antioxidant, anti-inflammatory, antimicrobial and immunotoxic.

Results

The present paper highlights the secondary metabolites present in the species and their scientific uses. Ancient Ayurvedic treatise claims several other pharmacological activities, but scientific validation of some indications, including the exact mechanism of action, is underway.

Conclusion

This review compiles 30 years of data on species related to their phytochemistry, pharmacology, molecular mechanisms of bioactivity, recent advancements and possible future scope of applied and translational research.

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References

  1. ButolaJ.S. VasisthaR.K. MalikA.R. RwatM.S. North-Western part of Indian Himalayan Region.Intern. J. Phytomed. Rel. Indust.20168431310.5958/0975‑6892.2016.00039.3
     [Google Scholar]
  2. SarkerS. NaharL. Natural medicine: The genus Angelica.Curr. Med. Chem.200411111479150010.2174/092986704336518915180579
     [Google Scholar]
  3. PanZ.H. ZhuangT.D. YaoX.M. ShengN. A study on karyotypes and geographical distribution of Angelica and related genera (Umbelliferae) in China.J. Syst. Evol.1994325419424
     [Google Scholar]
  4. AgnihotriV.K. ThappaR.K. MeenaB. KapahiB.K. SaxenaR.K. QaziG.N. AgarwalS.G. Essential oil composition of aerial parts of Angelica glauca growing wild in North-West Himalaya (India).Phytochemistry200465162411241310.1016/j.phytochem.2004.07.00415381015
     [Google Scholar]
  5. LeeS.H. HanA.R. KangU. KimJ.B. SeoE.K. JungC.H. Inhibitory effects of furanocoumarins from the roots of Angelica dahurica on ionizing radiation-induced migration of A549 human non-small cell lung cancer cells.Nat. Prod. Commun.20201541934578X209150310.1177/1934578X20915036
     [Google Scholar]
  6. El-SaberG.B. ShaheenH.M. ElhawaryE.A. MostafaN.M. OmaymaA.E. SabatierJ.M. Folk medicinal uses and biological activities of genus Angelica- A review.Molecules202328126710.3390/molecules28010267
     [Google Scholar]
  7. JoshiR.K. Angelica (Angelica glauca and A. archangelica) oils.In: Essential Oils in Food Preservation, Flavor and Safety.Academic Press201620320810.1016/B978‑0‑12‑416641‑7.00021‑3
     [Google Scholar]
  8. LunzK. StappenI. Back to the roots—an overview of the chemical composition and bioactivity of selected root-essential oils.Molecules20212611315510.3390/molecules2611315534070487
     [Google Scholar]
  9. ChevallierA. Encyclopaedia of Medicinal Plants.LondonDorling Kindersley1996
     [Google Scholar]
  10. Gupta; Shankar, E.; Gupta, S. Chamomile: A herbal medicine of the past with a bright future. (Review)Mol. Med. Rep.20103689590110.3892/mmr.2010.37721132119
     [Google Scholar]
  11. PurohitV.K. AndolaH.C. HaiderS.Z. TiwariD. BahugunaY.M. GairolaK.C. ArunachalamK. Essential oil constituents of angelica glauca edgew. Roots: An endangered species from Uttarakhand Himalaya (India).Natl. Acad. Sci. Lett.201538544544710.1007/s40009‑015‑0395‑z
     [Google Scholar]
  12. D, A.; D, B.; G, C.J.; L, M.T. Trade, population study and conservation aspects of Choraka/Choru in Kumaun Himalayas.Sci. Res. Essays2015102647010.5897/SRE2014.6035
     [Google Scholar]
  13. LansdownR.V. Angelica sylvestris. In: IUCN Red List of Threatened Species; 2014T19620785A19621071
     [Google Scholar]
  14. Britannica. The Editors of Encyclopaedia. “Angelica”. ,2022 https//www.britannica.com/plant/angelica-plant (accessed on 5 April, 2023).
  15. Anonymous Agro-techniques of Selected Medicinal Plants.Ministry of Health & Family Welfare2014
     [Google Scholar]
  16. AryaP. MehtaJ.P. MauryaV.K. Methanolic extract of Angelica glauca edgew root and stem, a possible component of herbal medicines against respiratory infections. In Ind J. Pharma. Edu. Res.202155S2S552S56210.5530/ijper.55.2s.127
     [Google Scholar]
  17. GeorgeA.B. Fenaroli’s Handbook of Flavor Ingredients.CRC Press2023
     [Google Scholar]
  18. SowndhararajanK. DeepaP. KimM. ParkS.J. KimS. A review of the composition of the essential oils and biological activities of Angelica species.Sci. Pharm.2017853333810.3390/scipharm8503003328930168
     [Google Scholar]
  19. SajwanK. PandeB. SajwanS. RaiN. SharmaR.K. KhetwalK.S. Chemical investigation on roots of Angelica glauca. high altitude himalayan herb research & reviews.J. Pharmacol.2012221218
     [Google Scholar]
  20. IrshadM. ShahidM. AzizS. GhousT. Antioxidant., antimicrobial and phytotoxic activities of essential oil of Angelica glauca.Asian J. Chem.20112319471953
     [Google Scholar]
  21. CaoY. LiuJ. WangQ. LiuM. ChengY. ZhangX. LinT. ZhuZ. Antidepressive-like effect of imperatorin from Angelica dahurica in prenatally stressed offspring rats through 5-hydroxytryptamine system.Neuroreport201728842643310.1097/WNR.000000000000077828383321
     [Google Scholar]
  22. ChenX. SunW. GianarisN.G. RileyA.M. CumminsT.R. FehrenbacherJ.C. ObukhovA.G. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.J. Biol. Chem.2014289149600961010.1074/jbc.M113.53686224569998
     [Google Scholar]
  23. JainS.K. TripathiM. PathakS. WanjariM.M. Evaluation of antiseizure activity of essential oil from roots of Angelica archangelica Linn. in mice.Indian J. Pharm. Sci.201072337137510.4103/0250‑474X.7048721188050
     [Google Scholar]
  24. ThangaleelaS. SivamaruthiB.S. KesikaP. TiyajamornT. BharathiM. ChaiyasutC. A narrative review on the bioactivity and health benefits of alpha-phellandrene.Sci. Pharm.2022904576210.3390/scipharm90040057
     [Google Scholar]
  25. BouyahyaA. MechchateH. BenaliT. GhchimeR. CharfiS. BalahbibA. BurkovP. ShariatiM.A. LorenzoJ.M. OmariN.E. Health benefits and pharmacological properties of carvone.Biomolecules20211112180310.3390/biom1112180334944447
     [Google Scholar]
  26. AlyE. KhajahM.A. MasochaW. β-Caryophyllene, a CB2-receptor-selective phytocannabinoid, suppresses mechanical allodynia in a mouse model of antiretroviral-induced neuropathic pain.Molecules201925110611110.3390/molecules2501010631892132
     [Google Scholar]
  27. LichotaA. GwozdzinskiK. Anticancer activity of natural compounds from plant and marine environment.Int. J. Mol. Sci.201819113533353910.3390/ijms1911353330423952
     [Google Scholar]
  28. Parise-FilhoR. PastrelloM. CamerlingoP.C.E. SilvaG.J. AgostinhoL.A. de SouzaT. MagriM.F.M. RibeiroR.R. BrandtC.A. PolliM.C. The anti-inflammatory activity of dillapiole and some semisynthetic analogues.Pharm. Biol.201149111173117910.3109/13880209.2011.57579322014265
     [Google Scholar]
  29. PavelaR. ZabkaM. VrchotovaN. TriskaJ. KazdaJ. Selective effects of the extract from Angelica archangelica L. against Harmonia axyridis (Pallas)—An important predator of aphids.Ind. Crops Prod.201351879210.1016/j.indcrop.2013.08.073
     [Google Scholar]
  30. YangF. LinZ.W. HuangT.Y. ChenT.T. CuiJ. LiM.Y. HuaY.Q. Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.Sci. Rep.2019916991699910.1038/s41598‑019‑43518‑731061445
     [Google Scholar]
  31. MarcheseA. BarbieriR. CoppoE. OrhanI.E. DagliaM. NabaviS.F. IzadiM. AbdollahiM. NabaviS.M. AjamiM. Antimicrobial activity of eugenol and essential oils containing eugenol: A mechanistic viewpoint.Crit. Rev. Microbiol.201743666868910.1080/1040841X.2017.129522528346030
     [Google Scholar]
  32. FujisawaM. HaradaH. KenmokuH. MizutaniS. MisawaN. Cloning and characterization of a novel gene that encodes (S)-β-bisabolene synthase from ginger, Zingiber officinale.Planta2010232112113010.1007/s00425‑010‑1137‑620229191
     [Google Scholar]
  33. Nagoor MeeranM.F. JavedH. Al TaeeH. AzimullahS. OjhaS.K. Pharmacological properties and molecular mechanisms of thymol: Prospects for its therapeutic potential and pharmaceutical development.Front. Pharmacol.2017838038810.3389/fphar.2017.0038028694777
     [Google Scholar]
  34. LattéK.P. KayserO. TanN. KalogaM. KolodziejH. Unusual coumarin patterns of Pelargonium species forming the origin of the traditional herbal medicine umckaloabo.Z. Naturforsch. C2000557-852953310.1515/znc‑2000‑7‑809
     [Google Scholar]
  35. SonD. LeeG. OhS. LeeS. ChoiW. Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.Nutrients2015731945196410.3390/nu703194525781220
     [Google Scholar]
  36. WisneskiH.H. Determination of bergapten in fragrance preparations by thin layer chromatography and spectrophotofluorometry.J. Assoc. Off. Anal. Chem.197659354755110.1093/jaoac/59.3.5471270381
     [Google Scholar]
  37. ChaeJ. AnJ. KangW. MaJ. KwonK. Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats.Food Chem. Toxicol.201250103666367210.1016/j.fct.2012.06.04922771369
     [Google Scholar]
  38. OhS.R. OkS. JungT.S. JeonS.O. ParkJ.M. JungJ. RyuD.S. Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis.Asian Pac. J. Trop. Med.201710986487010.1016/j.apjtm.2017.08.01729080614
     [Google Scholar]
  39. XiongY. WangJ. YuH. ZhangX. MiaoC. MaS. The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma.Immunopharmacol. Immunotoxicol.201436534134810.3109/08923973.2014.94703525090633
     [Google Scholar]
  40. ZhaoC. JiaY. LuF. Angelica stem: A potential low-cost source of bioactive phthalides and phytosterols.Molecules20182312306510.3390/molecules2312306530477097
     [Google Scholar]
  41. TürkuçarA.S. Karaçeli̇kA.A. KaraköseM. Phenolic compounds, essential oil composition, and antioxidant activity of Angelica pur- purascens (Avé-Lall.) gill.Turk. J. Chem.202145395696610.3906/kim‑2101‑2834385879
     [Google Scholar]
  42. VenugopalaK.N. RashmiB.O. Review on natural coumarin lead compounds for their pharmacological activity.BioMed Research. Intern.2013201396324810.1155/2013/963248
     [Google Scholar]
  43. ChoiY.E. AhnH. RyuJ.H. Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages.Biol. Pharm. Bull.200023788488610.1248/bpb.23.88410919371
     [Google Scholar]
  44. TykheevZ.A. TaraskinV.V. EmedeevaA.B. DylenovaE.P. UrbagarovaB.M. RadnaevaL.D. Compositions of fatty acids and sterols from Angelica sylvestris.Chem. Nat. Compd.202056470971010.1007/s10600‑020‑03125‑9
     [Google Scholar]
  45. PasquaG. MonacelliB. SilvestriniA. Accumulation of essential oils in relation to root differentiation in Angelica archangelica L.Eur. J. Histochem.2009471879010.4081/81112685562
     [Google Scholar]
  46. ChauhanR.S. NautiyalM.C. CecottiR. MellaM. TavaA. Variation in the essential oil composition of Angelica archangelica from three different altitudes in Western Himalaya, India.Ind. Crops Prod.20169440140410.1016/j.indcrop.2016.08.044
     [Google Scholar]
  47. DukeA. Handbook of Medicinal herbs.CRC press200210.1201/9781420040463
     [Google Scholar]
  48. HaradaM. SuzukiM. OzakiY. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ.J. Pharmacobiodyn.19847530431110.1248/bpb1978.7.3046470928
     [Google Scholar]
  49. DotyR.L. Treatments for smell and taste disorders, A critical review.In: In Handbook of Clinical Neurology.Elsevier201945547910.1016/B978‑0‑444‑63855‑7.00025‑3
     [Google Scholar]
  50. BussmannR.W. Angelica adzharica Pimenov Angelica tatianae Bordz. Apiaceae.In: Ethnobotany of the Mountain Regions of Far Eastern Europe. Ethnobotany of Mountain Regions. BatsatsashviliK. KikvidzeZ. BussmannR. ChamSpringer202010.1007/978‑3‑030‑28940‑9_11
     [Google Scholar]
  51. ReadB.E. SchmidtC.F. The pharmacology of Tang Kuei.Exp. Biol. Med.192320739539610.3181/00379727‑20‑192
     [Google Scholar]
  52. KanW.L.T. ChoC.H. RuddJ.A. LinG. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.J. Ethnopharmacol.20081201364310.1016/j.jep.2008.07.02718718517
     [Google Scholar]
  53. KumarD. BhatZ.A. KumarV. ShahM.Y. Coumarins from Angelica archangelica Linn. and their effects on anxiety-like behavior.Prog. Neuropsychopharmacol. Biol. Psychiatry20134018018610.1016/j.pnpbp.2012.08.00422960104
     [Google Scholar]
  54. YeungH.C. Handbook of Chinese Herbs and Formulas.Los AngelesInstitute of Chinese Medicine1985
     [Google Scholar]
  55. SowndhararajanK. KimS. Neuroprotective and cognitive enhancement potentials of Angelica gigas nakai root: A review.Sci. Pharm.2017852212810.3390/scipharm8502002128452965
     [Google Scholar]
  56. PimenovM.G. KljuykovE.V. Notes on some Sino-Himalayan species of Angelica and Ostericum (Umbelliferae).Willdenowia200333112113710.3372/wi.33.33112
     [Google Scholar]
  57. DineshP. RasoolM. Herbal formulations and their bioactive components as dietary supplements for treating rheumatoid arthritis.In: Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases.Academic Press201938539910.1016/B978‑0‑12‑813820‑5.00022‑2
     [Google Scholar]
  58. The role of RNA interference in the control of leishmania RNA virus 1 infection.. Arts & Sciences Electronic Theses and Dissertations,201710.7936/K7M61HQW
     [Google Scholar]
  59. LuoL. ZhangH. ChenW. ZhengZ. HeZ. WangH. WangK. ZhangY. ANGELICA SINENSIS polysaccharide ameliorates nonalcoholic fatty liver disease via restoring ESTROGEN‐RELATED RECEPTOR α expression in liver.Phytother. Res.202337115407541710.1002/ptr.798237563852
     [Google Scholar]
  60. YangQ. PopuloS.M. ZhangJ. YangG. KodamaH. Effect of Angelica sinensis on the proliferation of human bone cells.Clin. Chim. Acta20023241-2899710.1016/S0009‑8981(02)00210‑312204429
     [Google Scholar]
  61. MéndezJ. PoceiroC.J. Furocoumarins from Angelica pachycarpa.Phytochemistry198322112599260110.1016/0031‑9422(83)80174‑5
     [Google Scholar]
  62. YoshiyukiK. HiromichiO. Effects of active compounds isolated from Angelica shikokiana on lipid metabolism in fat cells.J. Ethnopharmacol.198925326928010.1016/0378‑8741(89)90033‑02545976
     [Google Scholar]
  63. ShahS.D. LindC. In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signalling and function.Proc. Natl. Acad. Sci. 202211949e2214024119e221402413210.1073/pnas.221402411936449547
     [Google Scholar]
  64. TopalM. SarıkayaO.S.B. TopalF. Determination of Angelica archangelica ’s antioxidant capacity and mineral content.ChemistrySelect20216317976798010.1002/slct.202102282
     [Google Scholar]
  65. MurrayM.T. NowickiJ. Angelica Species. In: Textbook of Natural Medicine.Elsevier2020429432.e110.1016/B978‑0‑323‑43044‑9.00053‑4
     [Google Scholar]
  66. HärmäläP. VuorelaH. TörnquistK. HiltunenR. Choice of solvent in the extraction of Angelica archangelica roots with reference to calcium blocking activity.Planta Med.199258217618310.1055/s‑2006‑9614241529031
     [Google Scholar]
  67. SigurdssonS. GudbjarnasonS. Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum.Z. Naturforsch. C J. Biosci.2007629-1068969310.1515/znc‑2007‑9‑101118069242
     [Google Scholar]
  68. SoY.K. Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: Structure-activity relationships.J. Nat. Prod.200164568368511374978
     [Google Scholar]
  69. KwonY. KimH.P. KimM.J. ChunW. Acetylcholinesterase inhibitors from Angelica polymorpha stem.Nat. Prod. Sci.20172329710210.20307/nps.2017.23.2.97
     [Google Scholar]
  70. ElgoharyA.A. ShafaaM.W. RaafatB.M. RizkR.A. MetwallyF.G. SalehA.M. Prophylactic effect of Angelica archangelica against acute lead toxicity in albino rabbits.Rom. J. Biophys.200919259275
     [Google Scholar]
  71. SeoH.Y. YangS.H. ShimS.L. NoK.M. ParkK.S. SongK.D. KimK.S. Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb.Nat. Prod. Res.200721326527310.1080/1478641060112959817365718
     [Google Scholar]
  72. AćimovićM.G. PavlovićS.Đ. VargaA.O. FilipovićV.M. CvetkovićM.T. StankovićJ.M. ČabarkapaI.S. Chemical composition and antibacterial activity of Angelica archangelica root essential oil. Nat. Prod. Commun.20171221934578X170120010.1177/1934578X170120021630428212
     [Google Scholar]
  73. KimK.S. YangH.J. ChoiE.K. ParkY.J. ChoD.H. AhnK.S. LeeJ.H. LeeS-G. UmJ.Y. JungH-J. JungS-K. JangH-J. The multi-target antibiotic efficacy of Angelica dahurica Bentham et Hooker extract exposed to the Escherichia coli O157:H7.Biochip J.20115433334210.1007/s13206‑011‑5407‑6
     [Google Scholar]
  74. CavaleiroC. SalgueiroL. GonçalvesM.J. HrimpengK. PintoJ. PintoE. Antifungal activity of the essential oil of Angelica major against Candida, Cryptococcus, Aspergillus and dermatophyte species.J. Nat. Med.201569224124810.1007/s11418‑014‑0884‑225576097
     [Google Scholar]
  75. AgnihotriA. WazedA. DasA. AlagirusamyR. Insect-repellent textiles using green and sustainable approaches. The Impact and Prospects of Green Chemistry for Textile Technology.Elsevier201930732510.1016/B978‑0‑08‑102491‑1.00011‑3
     [Google Scholar]
  76. YangS.J. YaoQ.Q. LiY.N. ChenX.X. CuiS.X. BaiS.Y. WangF.L. A new chromone from Angelica polymorpha with cytotoxic activity.J. Asian Nat. Prod. Res.2012141767910.1080/10286020.2011.63118122263597
     [Google Scholar]
  77. KumarD. BhatZ.A. ShahM.Y. Anti-anxiety activity of successive extracts of Angelica archangelica linn. on the elevated t-maze and forced swimming tests in rats.J. Tradit. Chin. Med.201232342342910.1016/S0254‑6272(13)60049‑723297567
     [Google Scholar]
  78. KumarD. ShahM.Y. BhatZ.A. Angelica archangelica Linn. is an angel on earth for the treatment of diseases.Int. J. Nutr. Pharmacol. Neurol. Dis.201111365010.4103/2231‑0738.77531
     [Google Scholar]
  79. GaoZ. ZhangJ. WeiL. YangX. ZhangY. ChengB. YangZ. GaoW. SongC. MiaoW. WilliamsK. LiuC. XuQ. ChangY. GaoY. The protective effects of imperatorin on acetaminophen overdose-induced acute liver injury.Oxid. Med. Cell. Longev.2020202011710.1155/2020/802683832454943
     [Google Scholar]
  80. GuoJ. HuZ. YanF. LeiS. LiT. LiX. XuC. SunB. PanC. ChenL. Angelica dahurica promoted angiogenesis and accelerated wound healing in db/db mice via the HIF-1α/PDGF-β signaling pathway.Free Radic. Biol. Med.202016044745710.1016/j.freeradbiomed.2020.08.01532853721
     [Google Scholar]
  81. GuD.R. YangH. KimS.C. HwangY.H. HaH. Water extract of Angelica dahurica inhibits osteoclast differentiation and bone loss.Int. J. Mol. Sci.202324191471510.3390/ijms24191471537834161
     [Google Scholar]
  82. MaJ. HuangJ. HuaS. ZhangY. ZhangY. LiT. DongL. GaoQ. FuX. The ethnopharmacology, phytochemistry and pharmacology of Angelica biserrata – A review.J. Ethnopharmacol.201923115216910.1016/j.jep.2018.10.04030408534
     [Google Scholar]
  83. KainturaD. AziemS. IqbalK. Economic potential of Angelica glauca Edgew, an endangered plant of Western Ghats. G-.J. Environ. Sci. Technol.2019651218
     [Google Scholar]
  84. GumbleS.P. NimbalkarM.D. BidwaiV.R. DeshmukhA.R. Examination of ghrita on various types of chronic diseases in pediatrics.Pediatr. Health Res.2018313910.21767/2574‑2817.100028
     [Google Scholar]
  85. DalaiS. MohapatraB. DwivediL. (Guduchi)from vedic to modern era, a review.Asian J. Pharma. Res. Devel.2013165261
     [Google Scholar]
  86. RautR.G. Analytical study of Balaashwagandha Taila.Ayurpharm Intern. J. Ayur Allied Sci.201436171176
     [Google Scholar]
  87. ChunekarK.C. Bhav Prakashan Nighantu Varanasi.Choukhamba Bharati Academy2012344345
     [Google Scholar]
  88. SemwalD.K. ChauhanA. KumarA. AswalS. SemwalR.B. KumarA. Status of Indian medicinal plants in the international union for conservation of nature and the future of ayurvedic drugs: Shouldn’t think about Ayurvedic fundamentals?J. Integr. Med.201917423824310.1016/j.joim.2019.04.00831076374
     [Google Scholar]
  89. JinsaI. MiharjanK. ChitraP. Effectiveness of sahacharaditailam fourteen times avarthiwith pre-medication in quality of life of parkinson’s disease as an add on to modern medicine.Intern. Ayurv. Med. J.2021631713178
     [Google Scholar]
  90. PrakashB. SinghP. GoniR. RainaA.K.P. DubeyN.K. Efficacy of Angelica archangelica essential oil, phenyl ethyl alcohol and α- terpineol against isolated molds from walnut and their antiaflatoxigenic and antioxidant activity.J. Food Sci. Technol.20155242220222810.1007/s13197‑014‑1278‑x25829603
     [Google Scholar]
  91. GururajaD. HegdeV. Ayurvedic management of systemic lupus erythematosus overlap vasculitis.J. Ayurveda Integr. Med.201910429429810.1016/j.jaim.2018.08.00731421962
     [Google Scholar]
  92. KimS.H. LeeS.W. ParkH.J. LeeS.H. Im, W.K.; Kim, Y.D.; Kim, K.H.; Park, S.J.; Hong, S.; Jeon, S.H. Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells.BMC Complement. Altern. Med.201818121810.1186/s12906‑018‑2277‑729402324
     [Google Scholar]
  93. SigurdssonS. OgmundsdottirH.M. GudbjarnasonS. The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L.Anticancer Res.2005253B1877188016158920
     [Google Scholar]
  94. KudohC. HoriT. YasakiS. UbagaiR. TabiraT. Effects of ferulic acid and Angelica archangelica extract (Feru-guard®) on mild cognitive impairment: A multicenter, randomized, double-blind, placebo-controlled prospective trial.J. Alzheimers Dis. Rep.20204139339810.3233/ADR‑20021133163900
     [Google Scholar]
  95. CalviñoC.I. TeruelF.E. DownieS.R. The role of the Southern Hemisphere in the evolutionary history of Apiaceae, a mostly north temperate plant family.J. Biogeogr.201643239840910.1111/jbi.12651
     [Google Scholar]
  96. SigurdssonS. GeirssonG. GudmundsdottirH. EgilsdottirP.B. GudbjarnasonS. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men.Scand. J. Urol.2013471263210.3109/00365599.2012.69539023323790
     [Google Scholar]
  97. ZhangZ.T. JiangY. QiY. GuanH. BaiL. ChenP. GaoW. ZhuangG.D. LuT. YanG. Comparative study on Angelica sinensis after different processing with yellow rice wine in color, aromas, chemical components, and antioxidant activities.Food Chem. X20231910082210.1016/j.fochx.2023.10082237780300
     [Google Scholar]
  98. LončarM. JakovljevićM. ŠubarićD. PavlićM. SlužekB.V. CindrićI. MolnarM. Coumarins in food and methods of their determination.Foods20209564564910.3390/foods905064532443406
     [Google Scholar]
  99. VashisthaR. NautiyalB.P. NautiyalM.C. Conservation status and morphological variations between populations of Angelica glauca Edgew. and Angelica archangelica Linn. in Garhwal Himalaya.Curr. Sci. Bangalore.2006915371546
     [Google Scholar]
  100. BishtA.K. BhattA. Rawal; Dhar, U. Assessment, extraction pattern and restoration through propagation of Angelica glauca, a critically endangered Himalayan medicinal herb.Biodivers. Int. J. Sci. Manag.20062210511310.1080/17451590609618103
     [Google Scholar]
/content/journals/npj/10.2174/0122103155287588240314065437
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A Deep Insight into Chemistry and Pharmacology of Genus Angelica.: An Up-to-date Systematic Review
Natural Products Journal, The 15, E190324228133 (2025); https://doi.org/10.2174/0122103155287588240314065437
/content/journals/npj/10.2174/0122103155287588240314065437
/content/journals/npj/10.2174/0122103155287588240314065437
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  • Article Type:     Review Article
Keyword(s): Angelica glauca; ayurvedic treatise; Chemistry; neuropharmacology; pharmacological aspects; phytochemistry

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