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Volume 3, Issue 2
  • ISSN: 0250-6882
  • E-ISSN: 0250-6882
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Abstract

Introduction/Background

Baclofen is a centrally acting GABA B receptor agonist, widely used for the treatment of neurological diseases ranging from hiccups to multiple sclerosis. As the drug is renally excreted, intoxication can rapidly develop in those patients with a reduced glomerular filtration rate. A strong index of clinical suspicion is essential to correctly diagnose the condition.

Case Presentation

We report a case series of patients with advanced kidney disease and baclofen-induced encephalopathy that settled with discontinuation of the drug and hemodialysis sessions.

Conclusion

We report this cluster of patients with baclofen toxicity to highlight the common occurrence of neurotoxicity after its use in patients with end-stage renal disease and its resolution after cessation of the drug and hemodialysis sessions.

© 2022 Bentham Science Publishers
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2022-09-01
2025-01-20

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/content/journals/nemj/10.2174/03666220909092340
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  • Article Type:     Case Report
Keyword(s): Baclofen; Encephalopathy; ESKD; Hemodialysis; Kidney Disease; Neurotoxicity

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