Transethosomal Carrier of Curcumin for Improved Topical Delivery: Optimization, In-vitro and Stability Assessment

Objective: Currently, there is a clear lack of effective topical treatments for psoriasis. In light of this unaddressed requirement, the work intends to develop, enhance, and assess the effectiveness of a curcumin transethosomal gel for managing psoriasis. This work signifies the delivery of a potential solution to fill the gap in topical psoriasis treatment. Materials and Methods: Curcumin-loaded transethosomes were prepared using a mechanical dispersion method. An initial study was conducted to determine the ideal concentrations of Lipoid S100 and Isopropyl Myristate (IPM). To refine the ultimate transethosomal formulation, a full factorial design (3²) was employed, incorporating different levels of Lipoid S100 and IPM. Drug release investigations and pharmacokinetics assessments of curcumin concentrations were performed using a specialized dissolution apparatus and an animal model, respectively. Results: The characterization profile and analytical examinations have affirmed the stability of the formulation throughout the study duration. Our findings indicate that the drug release mechanism conforms to a diffusion pattern akin to Fickian transport. Furthermore, In-vivo investigations revealed that the curcumin concentration in the bloodstream after oral administration was significantly superior to that of the conventional formulation. Conclusion: Using curcumin-loaded transethosomes extends drug contact time and facilitates controlled drug release, leading to enhanced bioavailability, decreased dosage needs, and heightened patient safety.