Letters in Organic Chemistry - Volume 21, Issue 2, 2024

Tuberculosis is a serious infectious disease caused by Mycobacterium tuberculosis (Mtb), also known as Koch’s bacillus. The involvement of latent forms and resistant strains has aggravated the situation, making the disease a serious public health problem.The objective of the study was to synthesize and evaluate ten new compounds containing camphor nucleus coupled to quinolinic derivatives as probable inhibitors of sens Read More

An alternative method for the synthesis of 2-heteroaryl or alkynyl benzo[b]thiophene or furan derivatives via direct palladium-catalyzed cross-coupling of 2-benzo[b]thiophene or furan aluminum with heteroaryl or alkynyl bromides, respectively, has been successfully developed. This case is remarkable as the same catalytic system could simultaneously produce either 2-substituted benzo[ b]thiophene or furan derivatives.

Pyrazolo bridged quinolones scaffolds are an important building block in many of the medicinally active new chemical entities. In the current work, synthesis of phenyl-4-(1H-pyrazol-5-yl) conjugated with 1H-pyrazolo[3,4-b]quinolin-5(4H)-ones derivatives has been achieved by one-pot threecomponent reaction of 3-methyl-1-phenyl-1H-pyrazol-5-amine 1, 5,5-dimethylcyclohexane-1,3-diones 2, and 1H-pyrazole-5-carbald Read More

Heterocyclic compounds and their derivatives epitomize the building blocks of many biological entities, e.g., alkaloids, antibiotics, enzymes, hormones, vitamins, and others that are abundant in nature. The Vilsmeier-Haack reaction has fascinated organic chemists due to its significant use in the synthesis of numerous heterocycles. This analytical evaluation provides a scrutinized overview of the literature on the synthes Read More

A new pyrrolidinyl-isosteviol bifunctional organocatalyst was synthesized, which was applied to catalyze the asymmetric Michael addition between cyclohexanone and nitroolefins. With 10 mol % of the organocatalyst, the reaction proceeded in water in high yields (up to 99%) with excellent diastereoselectivities (anti/syn up to 98:2) and good enantioselectivities (up to 90% ee). The design of the proline-isosteviol conjugates a Read More

This study investigates the use of ionic liquids (ILs) immobilized on HT-clay as catalysts for the Baylis-Hillman reaction. The catalytic system comprised three different types of ILs ([HIM]Im, [BIM]Im, [EIM]Im) and exhibited high reactivity, and the B-H products were obtained in good yield, which is superior to previously reported catalytic systems, whether they were heterogeneous or homogeneous. The HT-clay immobilized Read More

This study deals with the density functional theory calculations of eco-friendly designed nonionic sugar-based surfactants (SurfRing and SurfLinear). Then, it compares the results with the structural and electronic properties of a fatty alcohol surfactant (SurfFA). All geometry optimizations and energy calculations were performed using M06-2X functional and 6-31G(d,p) basis sets. The quantum chemistry reactivity parameters s Read More

Isatin-derivatives are an important class of nitrogen-containing heterocyclic compounds in organic synthesis. On the other hand, 1,3-thiazoles are 5-membered heterocyclic compounds containing nitrogen and sulphur atoms. Hydrazinyl thiazoles are often prepared through the classical condensation of aldehydes or ketones with thiosemicarbazide to yield thiosemicarbazones, which will then undergo heterocyclization wit Read More

In literature, dimethyl sulfoxide (DMSO) catalyzed bromination of arenes and heteroarenes is reported. In this study, simple, mild, and chemoselective N-bromosuccinimide (NBS) mediated monobromination of arenes and heteroarenes using butadiene sulfone as a catalyst is reported.Butadiene sulfone is a good substitute for DMSO as it is volatile, easy to recover and recycle, and environment- friendly. The m Read More

Utilization of α,α-dihalocarbonyl compounds as synthetic equivalents to α-halocarbonyl compounds has been explored in the synthesis of a wide range of highly useful heterocycles and α- functionalized ketones. The continuously growing demand of α,α-dibromoketones, as highly reactive and mild synthetic precursors/intermediates, to carry out selective organic transformations, prompted us to investigate their potential applic Read More

1,3-dimethyl-4,5-diaminouracil has been used as an efficient protecting group for the carbonyl moiety in sugars by the formation of the imine group. The protection reaction is carried out under mild conditions, the yields are quantitative in most of the cases, and the protecting group is completely recovered and reused. After per-acetylation, deprotection is accomplished at room temperature with aqueous formic acid to Read More