Letters in Organic Chemistry - Volume 21, Issue 1, 2024

Natural products have been created by nature and are derived from organisms such as plants or microorganisms. The natural compounds are isolated from natural sources in very small quantities, making it difficult for the form to achieve the compounds' good yields. The last is relevant for doing biological essays and chemical structure elucidation. Besides, they have diverse chemical structures, which have inspired organic Read More

The addition of camphor and oxone¦reg; during the epoxidation led to the synthesis of seven novel epoxides. Since the tri-substituted double bond of -cyano-cinnamates has been epoxidized, the reaction is easier to carry out and cleaner, producing a high yield of epoxides. Several molecules with industrial applications will result from the selective ring opening of epoxides.

In this study, a new fluorous aza-crown ether derivative (1) conjugated with two Bfp (bisfluorous chain type propionyl) groups was prepared; then, the partition ratios of 1 in biphasic systems using FC 72 and several organic solvents were investigated. Next, the activities of 1 in an FC 72/acetonitrile biphasic system were assessed via the SN2-type acetoxylation reaction using 2- (bromomethyl)naphthalene and potassiu Read More

Essential oils are widely used in cosmetic and personal care products. These essential oils such as menthol, limonene, rose oil, and jasmine oil are extracted from plants and also prepared in the laboratory. Menthol is the most common cyclic monoterpene alcohol, which has been produced due to its demand in various industries worldwide. In the literature, there were many protocols reported for the synthesis of menthols from n Read More

Chalcones are important scaffolds in the field of medicinal chemistry due to the presence of α,β-unsaturated ketone functionality. They are usually synthesized by reacting an aldehyde with acetophenone in the presence of acid or base using the Claisen-Schmidt condensation reaction. Numerous chalcone derivatives have been developed due to the simplicity of their synthesis, and they have intriguing biological activity t Read More

Green' methodologies have become the main route for producing selenium nanoparticles (SeNPs), as they do not involve toxic substances that can increase the reactivity of the synthesized nanoparticles and are practical and inexpensive. Extracts from plants, bacteria, fungi, yeasts, ascorbic acid, and polysaccharides are used to produce these nanoparticles. Plant extracts contain phytochemicals that act as reducing and stabi Read More

The 1,2,5-oxadiazole framework has garnered a lot of interest among many nitrogen heterocycles because of its capacity to give off NO under physiological circumstances. Because of this, major efforts by chemical scientists have been made to create novel drug possibilities in medicinal, material, and agriculture science that include the NO-donor 1,2,5-oxadiazole N-oxide subunit coupled to a known drug or a possible phar Read More

This research work presents the use of base-modified Tunisian Smectite as catalysts for the condensation of Knoevenagel. The prepared clay-catalysts were characterized via FTIR and XRD studies. A series of condensation reactions based on ultrasonic irradiation of various types of active methylene compounds and a variety of aryl aldehydes have shown the high efficacy of prepared catalysts. The stability and catalytic per Read More

With multi-drug-resistant tumours continuously evolving, developing new drugs with enhanced efficacy is essential. This study aims to synthesise flavonoid Mannich bases and evaluate their cytotoxic activity. The flavonoids isolated from the leaves of Muntingia calabura were used as reactants for the synthesis. Twenty flavonoid Mannich bases were synthesised via the Mannich reaction. Cytotoxic activity of the parent compound Read More

In this research, poly (4-vinyl pyridine)-supported nickel oxide nanoparticles (P4VP-NiO nanocatalyst) as an efficient recyclable catalyst have been prepared and used for the regioselective synthesis of triazole derivatives. The nanocatalyst we characterized by Fourier-transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD Read More

An improved synthesis of the monoterpene cyclic ketone karahanaenone, an ingredient in cosmetics, perfumery, and pest-control agents, is reported. The synthesis uses linalyl acetate as the starting material, which is converted to the epoxide with m-CPBA and submitted to an anhydrous lithium perchlorate catalyzed rearrangement to the corresponding ketone. Hydrolysis and thermolysis of the ketone afford karahanaeno Read More