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- Volume 21, Issue 11, 2024
Letters in Organic Chemistry - Volume 21, Issue 11, 2024
Volume 21, Issue 11, 2024
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Cholesterol-Based B-Ring 2H-Pyran: Synthesis and Reaction Mechanism by Using Density Functional Theoretical Study
Authors: Priyanka, Himanshi Kumar and Kamlesh SharmaThe steroidal B-ring 2H-pyran 2 is synthesized by reacting steroidal B-ring α,β- unsaturated ketone 1 and 2-cyano-N-methylacetamide by refluxing for 18 h in methanol in the presence of a catalyst, i.e., chitosan. The product is obtained with a yield of 67%. The structure of the final product 2 is confirmed by utilizing IR, Mass, 13C and 1H NMR spectra. The reaction mechanism of the steroidal pyran ring formation is explored in th Read More
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A Linear and Stereoselective Approach for the Synthesis of Dapoxetine from Benzaldehyde
Authors: Ramakoteswara R. Chinta, Kumaraswamy Paridala and Vijay Kumar TulamIn addition to providing a succinct pathway for the stereoselective synthesis of dapoxetine, a potent SSRI employed in the treatment of premature ejaculation, this study highlights the strategic use of Ellman's sulfinamide as a chiral auxiliary. The key method involves the diastereoselective allylation of (S,E)-N-Benzylidenesulfinamide, resulting in the desired S-configuration critical for the pharmacological activity of dapoxetin Read More
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[EMIM] [OAc]: An Efficient Ionic Liquid Medium for the Synthesis of New 4-(furan/pyrrole/thiophene-2-yl)-3, 4-dihydro-1H-chromeno [4,3-d] pyrimidine-2,5-diones and Molecular Docking Studies
An efficient synthesis of Chromeno[b]pyrimidine derivatives 4 has been achieved by treating 4-hydroxy-2H-chromen-2-one 1, furan-2-carbaldehyde / 1H-pyrrole-2-carbaldehyde/ thiophene-2- carbaldehyde 2, and urea/thiourea 3 at 65-70 °C for 90-120 min using 1-Ethyl-3-methylimidazolium acetate as ionic liquid and medium with good yields 86-90%. This synthetic method has numerous advantages, including high yields, a si Read More
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A Brief Review Depending on the Chemistry of Isatin in Single Pot Technique Towards the Construction of Significant and Valuable Heterocyclic Scaffolds
More LessThe term isatin and its derivative-based MCRs have emerged over the years as a versatile, environment-friendly, and very promising platform for the construction of highly enabling bioactive organic scaffolds such as drugs, natural products, pharmaceuticals etc. In the world of recent advancements, the one-pot strategy based on isatin has come to the forefront of synthetic chemistry for the activation of small organic Read More
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Fireballs-Like Explosive Peroxides Produced by the Brown-rot Fungus
More LessFireballs are unusual and rare phenomena usually associated with thunderstorms, although sometimes they have been observed during earthquakes, volcano eruptions or in fair weather. There are still questions about their origination, features and interaction with the environment. In this work, a new model is shown to explain the formation of fireballs in fair weather from poplar cotton and peroxides produced by brow Read More
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Synthesis of Symmetrical and Unsymmetrical Tetrahydroxybiphenyls and their Evaluation as Amyloid-β Aggregation Inhibitors
Our group recently reported that the polyhydroxy aromatic compound 3,3′,4,4′- biphenyltetrol (2a) is a successful inhibitor of amyloid-β peptide (Aβ) aggregation, decreasing Aβ aggregation by 50 % when present in equimolar concentrations. In the present study, several additional biphenyltetrols were prepared and examined for their in vitro activity against aggregation of Aβ to investigate the effect of the relative p Read More
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Design and Synthesis of Novel Heterocycles Utilizing 4,6-Dimethyl-1- ((4-methylthiazol-2-yl)amino)-2-oxo-1,2-dihydropyridine-3-carbonitrile
More LessNovel hydrazones 4, 5, and oxime 6 were produced from the reaction of ketone 3 with hydrazine, phenylhydrazine, and hydroxylamine HCl, respectively. One pot multicomponent reaction of chalcones 7a-c, 3-(1H-indol-3-yl)-3-oxopropanenitrile 8, and ammonium acetate in MeOH at reflux temperature gave 2-(1H-indol-3-yl)-nicotinonitrile derivatives 10-12. Additionally, a one-pot reaction of chalcone 7a, malononitrile Read More
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Electron Properties of Baicalein and its Derivatives via Quantum Chemistry Calculation: The Effect of Hydroxyl-substitution at A and C Rings
By Xiong LiThe electron properties of baicalein-family are of great importance in influencing its properties and corresponding bioactivities. In this work, we conducted comprehensive quantum chemistry calculations on pristine baicalein, and its two hydroxyl-substituted derivatives where the hydroxylsubstitution respectively occur at A and C rings. By contrasting with each other, the effects of the hydroxyl-substitution on the el Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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