Letters in Organic Chemistry - Volume 21, Issue 10, 2024

The year 1891 is considered as a historic year in chemical science due to the introduction of novel heterocyclic compounds by P. Biginelli. The classical Biginelli reaction offers 3,4- dihydropyrimidin-2(1H)-ones/thiones in occupancy of acids like Broansted and Lewis. Multifaceted Dihydropyrimidones (DHPMs) have gained much importance due to their high biological activities. Several nanoparticles, zeolites and m Read More

Impurities are an integral part of drug substances, even though they have not been studied in the pharmacological evaluation of the Benefit-Risk (BR) profiles. Hence, understanding their origin and controlling them have prime importance during drug substance development. The structures of some of the impurities in lisdexamfetamine dimesylate, a central nervous system stimulant drug, have been confirmed based on literatu Read More

Clofarabine (1) is an anticancer agent used to treat acute leukemia. This work discloses the efforts to develop a convenient, environmentally benign, and high-yielding synthetic protocol leading to Clofarabine (1). The synthesis includes bromination of 2-deoxy-2-β-fluoro-1,3,5-tri-O-benzoyl-1- α-D-ribofuranose (6), followed by C-N coupling with a 2,6-dichloro purine (4) and selective amination consecutively. The proposed tota Read More

Two polymer particles have been prepared by the reaction of N, N, N', N'-tetrakis(4- aminophenyl)-1,4-benzenediamine, 4, 4-biphenyldialdehyde and isophthalaldehyde, and characterized by SEM, FTIR and XRD. Based on methylene blue as the model pollutant, the adsorption properties of two polymer particles have been observed by using different adsorbent dosages, adsorption times and adsorption temperatures. Experimen Read More

Sarcococca saligna (D. DON) Muel is a vital plant with several steroidal alkaloids and is effective against syphilis, liver diseases, gastrointestinal tract disease, infections, and inflammation. The present study aimed to investigate the in vitro antioxidant activities and phenolic profile of S. saligna. High-performance liquid chromatography (HPLC) analysis has shown the presence of twelve phenolics namely kaempferol-3-O-glucosid Read More

A facile and green strategy for the Knoevenagel condensation reaction of aryl aldehydes and active methylene compounds using [Bmim][CF3COO] ionic liquid as a solvent and a catalyst has been introduced. The method features some advantages such as good to excellent yield of products, relatively short reaction time, mild reaction conditions, broad substrate scope, and scalability. Moreover, the ionic liquid solvent could be Read More

A novel advancement has emerged in the realm of catalysis with the development of an innovative method for the Ipso-hydroxylation of arylboronic acids. This approach harnessed the power of bio-compatible polydopamine-coated magnetite support (Fe3O4@PDA) in conjunction with a copper salt, forming a heterogeneous catalytic environment. The resulting catalytic system facilitated oxidative hydroxylation under m Read More

In this study, the synthesis of N-alkyl-3-(indol-3-yl)pyrazoles was carried out from Ag2CO3 catalyzed regioselective aza-Michael addition of 5-(indol-3-yl)-1H-pyrazoles to α, β-unsaturated carbonyl compounds. In the presence of 10 mol% of Ag2CO3, the reaction smoothly occurred in dichloroethane (DCE) at 120°C to preferentially afford a series of N-alkyl-3-(indol-3-yl)pyrazoles in high yields with good regioselectivity. I Read More