Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders) - Volume 25, Issue 3, 2025

In recent years, the prevalence of diabetes has gradually increased and has become one of the main chronic non-communicable diseases, threatening the lives of people. Diabetic complications are characterized by high incidence and poor prognosis. Once they occur, conventional drugs are difficult to reverse, so it is extremely urgent to seek new drugs to treat diabetes and complications. Puerarin is an isoflavone d Read More

BackgroundDiabetic wound represents a serious issue with a substantial impact and an exceptionally complex pathology affecting patients’ mental health and quality of life. So, we have developed a novel 3D organo-hydrogel nanocomposite of polydopamine/TiO2 nanoparticles and cu (PDA-TiO2@Cu) and examined its efficacy in diabetic wound healing.MethodsForty-five adult male albino rats were divided into normal control Read More

ObjectiveThe study aimed to investigate the efficacy and safety of semaglutide in weight loss in non-diabetic people.MethodsIn this study, 84 non-diabetic people who used semaglutide to lose weight in the outpatient department of our hospital from January 1, 2022, to June 30, 2022, were enrolled and compared for changes in body weight, waist circumference, Body Mass Index (BMI), fasting blood glucose, blood pressure, Read More

BackgroundCalcitonin (CT) is a sensitive serum marker of medullary thyroid carcinoma usually detected via immunoassays; however, its levels are easily disturbed by several endogenous factors.ObjectiveThe study aimed to discuss a case of suspected interference resulting in aberrant CT values and review previous reports of CT interference.MethodsA female patient visited our clinic with a physical ultrasound examination Read More

Background and AimsInflammatory Bowel Disease (IBD) is a refractory disease with repeated attacks, and there is no accurate treatment target at present. Dipyridamole, a phosphodiesterase (PDE) inhibitor, has been proven to be an effective treatment for IBD in a pilot study. This study explored the therapeutic target of IBD and the pharmacological mechanism of dipyridamole for the treatment of IBD.Materials and Met Read More

ObjectivePrimary Hyperparathyroidism (PHPT) is a common disease, frequently diagnosed in post-menopausal women, among whom Osteoporosis (OP) is a common finding. To date, no study has specifically evaluated the asymptomatic PHPT (aPHPT) patients without OP, in particular post-menopausal women who are exposed to an increased risk of developing OP.Materials and MethodsThis study involved a retrospective cr Read More

BackgroundHonokiol is a natural polyphenolic compound extracted from Magnolia officinali, which is commonly used material in Chinese herbal medicine, has a variety of biological functions, including anti-tumor, anti-oxidant, anti-inflammation, anti-microbial and anti-allergy. Although honokiol has numerous beneficial effects on human diseases, the underlying mechanisms of tumor metastasis are still unclear. Previousl Read More

IntroductionHypophysitis is an inflammatory disorder of the pituitary gland. It can manifest variously, with endocrinological and neuro-ophthalmologic symptoms and signs, due to the compression of sellar and parasellar structures.Case RepresentationAlthough hypophysitis is rare, this pituitary disease can occur during pregnancy or in the postpartum period. In this report, we describe the case of a woman with parti Read More