Skip to content
2000
Volume 25, Issue 3
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873

Abstract

Introduction

Hypophysitis is an inflammatory disorder of the pituitary gland. It can manifest variously, with endocrinological and neuro-ophthalmologic symptoms and signs, due to the compression of sellar and parasellar structures.

Case Representation

Although hypophysitis is rare, this pituitary disease can occur during pregnancy or in the postpartum period. In this report, we describe the case of a woman with partial hypopituitarism secondary to autoimmune hypophysitis who, five years after the diagnosis and the immunosuppressive treatment, had an uneventful pregnancy and successfully delivered a healthy infant at term.

Conclusion

We reported the clinical history of the patient and the evolution of the disease and also reviewed the management and treatment of autoimmune hypophysitis during pregnancy.

Loading

Article metrics loading...

/content/journals/emiddt/10.2174/0118715303314953240719044233
2024-07-30
2025-05-22
Loading full text...

Full text loading...

References

  1. RawanduzyC.A. Winkler-SchwartzA. CouldwellW.T. Hypophysitis: Defining histopathologic variants and a review of emerging clinical causative entities.Int. J. Mol. Sci.2023246591710.3390/ijms2406591736982990
    [Google Scholar]
  2. ChiloiroS. CapoluongoE.D. TartaglioneT. GiampietroA. BianchiA. GiustinaA. PontecorviA. De MarinisL. The changing clinical spectrum of hypophysitis.Trends Endocrinol. Metab.201930959060210.1016/j.tem.2019.06.00431345630
    [Google Scholar]
  3. ChansonP. Other pituitary conditions and pregnancy.Endocrinol. Metab. Clin. North Am.201948358360310.1016/j.ecl.2019.05.00531345525
    [Google Scholar]
  4. PreteA. SalvatoriR. FeingoldKR. Hypophysitis.EndotextSouth Dartmouth (MA) MDText, Inc2021
    [Google Scholar]
  5. ShenK. CadangC. PhillipsD. BabuV. Unique case of lymphocytic hypophysitis with normal pituitary hormone serology mimicking a non-functioning pituitary adenoma.BMC Endocr. Disord.20242412010.1186/s12902‑024‑01546‑z38326790
    [Google Scholar]
  6. ChourpiliadiC. PaparodisR. Physiology, Pituitary Issues During Pregnancy. StatPearlsTreasure Island (FL) StatPearls Publishing2023
    [Google Scholar]
  7. GoudieR.B. PinkertonP.H. Anterior hypophysitis and hashimoto’s disease in a young woman.J. Pathol. Bacteriol.196283258458510.1002/path.170083024113900798
    [Google Scholar]
  8. BrandesJ.C. CerlettyJ.M. Pregnancy in lymphocytic hypophysitis: case report and review.Wis. Med. J.1989881129322690469
    [Google Scholar]
  9. LuZ. YangG. BaJ. DouJ. MuY. LuJ. Spontaneous pregnancy in a patient with a relapse of lymphocytic hypophysitis successfully treated with azathioprine and glucocorticoids.Endocrine201139329629710.1007/s12020‑011‑9458‑121442379
    [Google Scholar]
  10. ChiloiroS. CapoluongoE.D. TartaglioneT. BianchiA. GiampietroA. AngeliniF. ArenaV. PontecorviA. De MarinisL. Human leucocyte antigens coeliac haplotypes and primary autoimmune hypophysitis in caucasian patients.Clin. Endocrinol. (Oxf.)201888569269910.1111/cen.1356629418012
    [Google Scholar]
  11. ChiloiroS. RussoF. TartaglioneT. CapoluongoED. Molecular and genetic immune biomarkers of primary and immune-therapy induced hypophysitis: From laboratories to the clinical practice.J Pers Med.202111101026
    [Google Scholar]
  12. ChiloiroS. CapoluongoE.D. AngeliniF. MariottiF. GrandeG. StiglianoE. VincenzoniF. BianchiA. GiampietroA. MilardiD. TartaglioneT. UrbaniA. PontecorviA. De MarinisL. Di ZenzoG. Autoantibody reactivity profile of primary autoimmune hypophysitis patients: preliminary results.Endocrine202276122422710.1007/s12020‑021‑02937‑134797510
    [Google Scholar]
  13. ChiloiroS. GiampietroA. AngeliniF. ArenaV. StiglianoE. TartaglioneT. MattognoP.P. D’AlessandrisQ.G. LaurettiL. PontecorviA. De MarinisL. BianchiA. Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: a pilot study.Endocrine202173230831510.1007/s12020‑021‑02612‑533484410
    [Google Scholar]
  14. ChiloiroS. TartaglioneT. AngeliniF. BianchiA. ArenaV. GiampietroA. MormandoM. SciandraM. LainoM.E. De MarinisL. An overview of diagnosis of primary autoimmune hypophysitis in a prospective single-center experience.Neuroendocrinology2017104328029010.1159/00044654427165294
    [Google Scholar]
  15. HoneggerJ. SchlafferS. MenzelC. DrosteM. WernerS. ElbeltU. StrasburgerC. StörmannS. KüppersA. Streetz-van der WerfC. DeutschbeinT. StiegM. RotermundR. MilianM. PetersennS. Pituitary Working Group of the German Society of Endocrinology Diagnosis of primary hypophysitis in germany.J. Clin. Endocrinol. Metab.2015100103841384910.1210/jc.2015‑215226262437
    [Google Scholar]
  16. KhareS. JagtapV.S. BudyalS.R. KasaliwalR. KakadeH.R. BukanA. SankheS. LilaA.R. BandgarT. MenonP.S. ShahN.S. Primary (autoimmune) hypophysitis: a single centre experience.Pituitary2015181162210.1007/s11102‑013‑0550‑924375060
    [Google Scholar]
  17. WangS. WangL. YaoY. FengF. YangH. LiangZ. DengK. YouH. SunJ. XingB. JinZ. WangR. PanH. ZhuH. Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18 years.Clin. Endocrinol. (Oxf.)201787217718410.1111/cen.1335428423475
    [Google Scholar]
  18. HoneggerJ. GieseS. Nasi-KordhishtiI. DoneganD.M. Pregnancy-related hypophysitis revisited.Eur. J. Endocrinol.20231882R1R1210.1093/ejendo/lvad00336655394
    [Google Scholar]
  19. GubbiS. Hannah-ShmouniF. StratakisC.A. KochC.A. Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.Rev. Endocr. Metab. Disord.201819433534710.1007/s11154‑018‑9480‑130547288
    [Google Scholar]
  20. BiswasM. ThackareH. JonesM.K. Bowen-SimpkinsP. Lymphocytic hypophysitis and headache in pregnancy.BJOG2002109101184118610.1111/j.1471‑0528.2002.01158.x12387476
    [Google Scholar]
  21. ChiloiroS. TartaglioneT. CapoluongoED. Hypophysitis outcome and factors predicting responsiveness to glucocorticoid therapy: A prospective and double-arm study.J. Clin. Endocrinol. Metab.20181031038773889
    [Google Scholar]
  22. RayD.K. YenC.P. VanceM.L. LawsE.R. LopesB. SheehanJ.P. Gamma Knife surgery for lymphocytic hypophysitis.J. Neurosurg.2010112111812110.3171/2009.6.JNS08117619558303
    [Google Scholar]
  23. PengL. ZhangP. ZhangX. LiJ. ZhaoJ. LiuJ. FeiY. ZhangW. ZhuY. ZhaoY. ZengX. Clinical features of immunoglobulin G4-related disease with central nervous system involvement: an analysis of 15 cases.Clin. Exp. Rheumatol.202038462663232083541
    [Google Scholar]
  24. YamaguchiS. SawamuraA. NakaguroM. Giant cell myocarditis with central diabetes insipidus: A case report.J. Cardiol. Cases.2019211811
    [Google Scholar]
  25. LiHT. WangST. QiuMC. Gynecomastia, obesity and underdeveloped testis and penis: suspected hypophysitis successfully cured with low dose of cyclosporine A.Chin. Med. J.20091222227912793
    [Google Scholar]
  26. HoneggerJ. GieseS. Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan’s syndrome.Minerva Endocrinol.201843446547529463076
    [Google Scholar]
  27. TartaglioneT. ChiloiroS. LainoM.E. GiampietroA. GaudinoS. ZoliA. BianchiA. PontecorviA. ColosimoC. De MarinisL. Neuro-radiological features can predict hypopituitarism in primary autoimmune hypophysitis.Pituitary201821441442410.1007/s11102‑018‑0892‑429752700
    [Google Scholar]
  28. KrishnappaB. ShahR. SarathiV. LilaA.R. SehembyM.K. PatilV.A. SankheS. ShahN. BandgarT. Early Pulse Glucocorticoid Therapy and Improved Hormonal Outcomes in Primary Hypophysitis.Neuroendocrinology2022112218619510.1159/00051600633744880
    [Google Scholar]
  29. DoneganD. SaeedZ. DelivanisDA. Outcomes of initial management strategies in patients with autoimmune lymphocytic hypophysitis: A systematic review and meta-analysis.J. Clin. Endocrinol. Metab.2022107411701190
    [Google Scholar]
/content/journals/emiddt/10.2174/0118715303314953240719044233
Loading
/content/journals/emiddt/10.2174/0118715303314953240719044233
Loading

Data & Media loading...


  • Article Type:
    Case Report
Keyword(s): autoimmune; hypoadrenalism; hypophysitis; hypopituitarism; Pregnancy; primary
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test