Drug Delivery Letters - Volume 5, Issue 3, 2015

Background: Natural polymers have been explored for drug delivery applications since decades, but limited success has been ascribed to their undesired physicochemical properties. Here, we demonstrate the grafting of an anionic and hydrophilic exopolysaccharide ‘gellan gum’with polyacrylamide using microwave irradiation and its potential in controlled delivery of aceclofenac. Methods: Grafting of gellan gum was Read More

Background: Hypertension is the most common cardiovascular disease worldwide and number one cause of death. Its related morbidities also impose huge economic burdens on population. The aim of the present investigation was to prepare thermal gel of Diltiazem Hydrochloride (DTZ) with different ratios of Poloxamer 407 (PLM 407) and Hydroxypropyl methylcellulose K100M (HPMC K100M) and to characterize their in v Read More

Objective: The aim of the present study was to investigate the effect of lauroyl macrogolglycerides (Gelucire 44/14) on Fluconazole (FZ) loaded solid lipid nanoparticles (SLN). Methods: FZ SLN were prepared using Glyceryl monostearate (GMS) and Gelucire 44/14 (GL) by microemulsion technique. The effect of concentration of GL on FZ SLN was studied. Similarly, the effect of formulation variables, drug content in lipid phase (X1) a Read More

Background: Colorectal cancer claims the life of millions of people globally. Chemoprevention is among the upcoming approaches for the treatment of colorectal cancer. It involves the use of therapeutic agents which are essentially not cytotoxic drugs but, however, impedes the carcinogenesis. Meloxicam (MLX) is one such agent which has the potential to be employed in the chemopreventive therapy of colorectal cancer. The ai Read More

Background: The objective of this study was to develop liposomal mucoadhesive drug delivery system for the delivery of curcumin via nasal route, to avoid hepatic first pass metabolism, to increase residence time and to investigate its nose to brain delivery potential. Methodology: The liposomes were prepared by solvent dispersion method using soya lecithin and cholesterol as a lipid phase and xanthan gum as a muco Read More

Background: Tablets are conventional dosage forms in health care systems and lot of efforts are made to control the release and subsequent oral absorption of drug via sustained release matrix tablets. Different polymers, natural and synthetic, are explored in this dimension to optimize the control over drug release and absorption. Different polymers presents different response to hydration, depending upon their swelling ind Read More

Background: Chitosan is a semi-synthetic biopolymer obtained by the alkaline deacetylation of chitin by the use of concentrated NaOH. It exhibits excellent biological properties such as biocompatibility, bioactivity biodegradation in the human body, immunological, antimicrobial and wound-healing activity. Chitosan is a unique amino carbohydrate, as it has dual-functionality as hydroxyl and amino groups in it. It is soluble in di Read More