Drug Delivery Letters - Volume 5, Issue 1, 2015

Traditional approach of formulating a new drug product is an exhaustive task and involves a number of resources like man, money, time and experimental efforts. While, using this Quality by Design (QbD) approach one can get the pharmaceutical product of desired (best) quality with minimizing above resources as well as knowing the influence of one factor over the desired associated process. Hence aim of this study Read More

Pectin and its modified forms have been used in the formulation of controlled and sustained drug delivery systems in recent years. Due to its biodegradability, easy availability and other benefits it is one of the first choices for both consumers and research scientists. Ease in modifications of the acidic group into amide, ester or other forms leads to the alterations in physical and chemical properties of pectin which further i Read More

The present study proposes to enhance solubility and eventually bioavailability of Atorvastatin Calcium (ATV) by preparing hot melt extrusion based orodispersible tablet (ODT). Tablet dosage forms displaying faster disintegration providing significant advantages over traditional techniques of solid dispersion (SD) were made by a speedy method. Dissolution analysis of the extrusion processed ATV using Soluplus in combination with Read More

The objective behind this study is to prepare a transdermal therapeutic system for aceclofenac and ameliorate to evaluate the influence of chemical permeation enhancer (oleic acid) on drug permeation through the human cadaver skin. The influence of permeation enhancer on permeation flux (J), enhancement ratio of flux (ERflux) and permeability coefficient (Pss) was compared with the control batch (without p Read More

The aim of the present research work was to develop and evaluate provesicular topical drug delivery system of indomethacin. The encapsulation of drug in vesicular structure prolongs the existence of the drug in the systemic circulation with improved bioavailability. The potential of proniosomes as a topical drug delivery system was explored by formulating proniosomal gel of indomethacin using coacervation-phase separation m Read More

The purpose was to develop monolithic gastroretentive system of rifaximin for prolonged release. Rifaximin (RFX) is a semi-synthetic antibiotic used in traveller's diarrhea and its local effect in stomach is desirable. A target quality product was defined and mucoadhesive strength, floating lag time and % drug release at three different time points were identified as critical quality attributes. Hydroxypropyl methylcellulose K100M (HP Read More

Multilayer tablet of tramadol hydrochloride was developed for the treatment of osteoarthritis. Multilayer tablet was comprised of immediate release layer, followed by drug-free retardant layers on either side of middle matrix layer. The sustained release effect was achieved by exploring the polysaccharide of tamarind kernel seed of Tamarindus indica. An extracted polysaccharide showed high swelling index and viscosity. Thr Read More