Drug Delivery Letters - Volume 5, Issue 2, 2015

Background: In the present competitive situation, pharmaceutical companies all over the world are mainly focusing on the quality of product for maximum consumer acceptance and market share. Regulatory authorities are also trying to develop the pharmaceutical manufacturing process and technology, which is more concerned about the quality. Methods: Various online data and industrial requirements were reviewed an Read More

Background: The aim of the present study was to design and characterize the enteric coated mucoadhesive microcapsules of esomeprazole magnesium by solvent evaporation technique using drug, ethylcellulose and mucoadhesive polymer of 1:1:1 ratio for improving the mean gastric residence time and oral bioavailability of the drug. Methods: Characterization of the mucoadhesive microcapsules through FT-IR, and DS Read More

Background: Emergence of new synthetic methods has given great impetus and momentum to nanotechnology which has revolutionized almost all disciplines of science and technology including medicine and pharmacy. The most fascinating aspect of nanomaterials is their vital role in drug delivery technology that makes use of them as drug carrying vehicles and delivers the carried drug to the diseased site in pre-determine Read More

Glibenclamide is a second generation hypoglycaemic agent used for the management of Diabetes Mellitus. In the present study, matrix type transdermal patches of Glibenclamide were prepared by solvent casting technique using various combinations of hydrophobic (ethyl cellulose) and hydrophilic (Polyvinyl pyrrolidone) polymer, named as batch A (without penetration enhancer) and batch B (with penetration enhancer). Read More

This study investigated the in vitro antimicrobial and antiproliferative activities of the methanol extract and of purified compounds from fruits of Ficus bubu Warb. Extensive chromatographic isolations provided two stilbenes, that were identified by NMR and mass spectrometry as trans-resveratrol 4a and piceid 7a, in addition to several other chemical compounds. It was found that trans-resveratrol 4a exhibited the best Read More

Background: Temperature-sensitive liposomes (TSLs) containing chemotherapeutic drugs offer the prospect of increased drug delivery and bioavailability at the diseased sites. This concept is applied to hydrophilic drugs, which can be encapsulated in the inner water-rich lumen of the liposomes. In order to extend the concept of TSL to a hydrophobic drug, such as docetaxel (DTX), this drug was modified at the hydroxyl Read More

Background: 7–hydroxy–14H–naphtho[2,3–a]phenothiazine–8,13–dione (AQATP) was synthesized by using iodobenzenediacetate as catalyst from 1,4–dihydroxyanthraquinone (1,4–AQ) which was isolated from Cassia tora seeds. Methods: They were then characterized by various spectral techniques. Single crystal X-ray diffraction studies revealed that AQATP crystallizes in orthorhombic space group. ADME Test was perfor Read More