Drug Delivery Letters - Volume 2, Issue 3, 2012

Reformulation of anti-tuberculosis drugs into dry powder particles for inhalation is a novel strategy that aims to increase therapeutically relevant drug concentration at the primary site of infection and to limit associated toxicity by avoiding or minimizing first-pass metabolism. Development of such formulations ultimately requires quantified evidence of the deposition, absorption and clearance of inhaled active ingredient. In thi Read More

The present study investigates the specific drug targeting of anti cancer drugs, such as carboplatin by incorporation into folate conjugated Solid Lipid Nanoparticles (SLN). Our results showed that SLN 5 has the greater entrapment efficiency of 87.50% and slow in-vitro drug release (65.31% of carboplatin was released in 12 hrs) among all the SLN formulations prepared by high speed homogenization using 23 factorial design. T Read More

To reduce the risk of infection in the treatment of long bone defects, implant materials can be provided with an antibiotic drug delivery system. A novel bone implant for the tissue engineering of critical long bone defects was developed by stacking embroidered scaffolds, seeded with mesenchymal human stem cells. Controlled drug release is to be integrated in this implant by coating the thread material with antibiotic Read More

This systematic review and meta-analysis is focusing on the evidences related to iontophoresis used to enhance the topical drug delivery through the skin in the treatment of inflammatory dysfunctions, acute soft tissue injuries and pain. A literature search in the databases, MEDLINE (PubMed), Pedro, and the Cochrane Database of Systematic Reviews was conducted. The methodological quality of the obtained studies was indep Read More

The aim of the presented work describes the formulation of compressed orally disintegrating tablet (ODT) using α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a binder/disintegrant. Preliminary investigations were focused on process and formulation optimisation which resulted in ODT containing 2% wt. TPGS with reasonable hardness and acceptable disintegration time but with high friability. The next stage of the Read More

High blood pressure (HBP) is a serious condition that can lead to coronary heart disease, stroke, kidney failure and other health problems. Management of HBP with the conventional dosage forms of the existing antihypertensive agents are challenging to the clinicians. Candesartan cilexetil (CC) is a newer class of antihypertensive agent which comes under angiotensin II receptor antagonist. The current commercial f Read More

The purpose of this work was to formulate a controlled release multiple emulsion of carbamazepine favorable for administration in pediatrics and geriatrics suffering from epilepsy, decreasing the dosing frequency, thereby improving patient compliance and providing a platform for personalized medicine. Two–step emulsification procedure was employed for the formulation using liquid paraffin oil, water, surfactants Read More

The goal of our study was to prepare carboplatin niosomes for enhanced delivery to cancer cells by thin film hydration technique using (cholesterol: surfactant) in the micromolar ratio of 30:100 and with/without the addition of charge inducing agents and Pluronic F 68. Photomicrographs of the formulations show the presence of multilamellar vesicles in the forumulation with Tween 80 and Pluronic F 68. The vesicle size of the for Read More