Drug Delivery Letters - Volume 2, Issue 4, 2012

The purpose of this study was to develop a solid nanoemulsion preconcentrate (NanOsorb) for poorly watersoluble drug sertraline (SRT). The liquid SNEDDS consisted of LabrafilM 2125 CS and Maisine 35-1 in 1:1 ratio as oil phase, Tween 80 as surfactant, Lauroglycol 90 as co-surfactant and active constituent sertraline free base. SRT free base, rather than commercially available hydrochloride salts (SRT.HCl) was used due to i Read More

Polysaccharides have attractive advantages for using in the field of pharmaceutics. In most cases, they are non toxic, biocompatible and plentiful. The presence of hydroxyl groups (always) and carboxylic acid groups (sometimes) permits crosslinking of the chains and obtaining hydrogels. These hydrogels present interesting swelling and mechanical properties. They have the capacity to entrap active compounds such as dr Read More

In order to achieve high bioactivity, low systemic side effects and prevention of high critical hypoglycaemic conditions of antidiabetic drugs in the treatment of diabetes mellitus, sustained and controlled delivery system is crucial. In this study, a three-dimensional (3-D) porous scaffold formulation was developed with the ability to release antidiabetic drugs in a controlled fashion. The gliclazide (GLZ), was successfully inc Read More

Gemcitabine hydrochloride (Gem HCL) is a drug of choice for the treatment of most cancers, as a single or in combination chemotherapy. However, its bioavailability is a major concern because of its short half life and highly hydrophilic nature. To tackle this problem work has been planned to prepare solid lipid nanoparticles (SLN) of Gem HCL and analyzed them for drug carrying capacity and efficacy in vitro. The Gem HCL loa Read More

Penetration of healthy skin by drugs in solution is normally very limited due to the excellent barrier function of the stratum corneum (the most superficial layer of the skin). The goal of delivery system is to get optimal therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species and some non ionic. This barrier can be overcome using iontophoresis: by applying an elect Read More

5-Fluorouracil (5-FU) is a hydrophilic drug with short plasma half-life. The objective of the current study was to prepare and optimize 5-FU loaded chitosan nanoparticles (CNPs) for controlled release. The nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions. A 23 central composite design (CCD) was employed to study the influence of formulation variables - concentration of Chitosan (X1), the co Read More

The aim of proposed research work was to develop a bioadhesive sustained release matrix tablets of zolmitriptan for treatment of migrane. Compression coating technology was used for preparing the tablets that released the drug unidirectionally. Drug loaded core tablets were prepared with mucoadhesive and sustained release polymers like Noveon AA1 Polycarbophil and hydroxypropyl methylcellulose (HPMC K4M) while Read More